Myc activates telomerase

Wang, J., Xie, L. Y., Allan, S., Beach, D., Hannon, G. J. (1998) Myc activates telomerase. Genes and Development, 12 (12). pp. 1769-1774. ISSN 08909369 (ISSN)

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Abstract

Telomere maintenance has been proposed as an essential prerequisite to human tumor development. The telomerase enzyme is itself a marker for tumor cells, but the genetic alterations that activate the enzyme during neoplastic transformation have remained a mystery. Here, we show that Myc induces telomerase in both normal human mammary epithelial cells (HMECs) and normal human diploid fibroblasts. Myc increases expression of hEST2 (hTRT/TP2), the limiting subunit of telomerase, and both Myc and hEST2 can extend the life span of HMECs. The ability of Myc to activate telomerase may contribute to its ability to promote tumor formation.

Item Type:	Paper
Uncontrolled Keywords:	hEST2 Myc Telomerase Tumorigenesis article carcinogenesis cell survival controlled study enzyme activation enzyme activity enzyme induction epithelium cell fibroblast gene mutation human human cell oncogene c myc priority journal protein expression Cell Division Cell Line DNA-Binding Proteins Gene Expression Humans Proteins Proto-Oncogene Proteins c-myc Recombinant Proteins RNA RNA, Messenger Tumor Cells, Cultured
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > Myc bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > telomerase
CSHL Authors:	Beach, David H. Hannon, Gregory J. Wang, Jing
Communities:	CSHL labs > Hannon lab
Depositing User:	Matt Covey
Date:	1998
Date Deposited:	09 Jan 2013 17:33
Last Modified:	14 Jan 2013 22:07
PMCID:	PMC316904
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/26479

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