Hammond, S. M., Caudy, A. A., Hannon, G. J.
(2001)
Post-transcriptional gene silencing by double-stranded RNA.
Nature Reviews Genetics, 2 (2).
pp. 110-119.
ISSN 14710056 (ISSN)
Abstract
Imagine being able to knock out your favourite gene with only a day's work. Not just in one model system, but in virtually any organism: plants, flies, mice or cultured cells. This sort of experimental dream might one day become reality as we learn to harness the power of RNA interference, the process by which double-stranded RNA induces the silencing of homologous endogenous genes. How this phenomenon works is slowly becoming clear, and might help us to develop an effortless tool to probe gene function in cells and animals.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Animalia
Harness
double stranded RNA
animal
biological model
gene silencing
metabolism
review
RNA processing
Animals
Models, Biological
RNA Processing, Post-Transcriptional
RNA, Double-Stranded |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA regulation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene silencing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Hannon lab
School of Biological Sciences > Publications |
| Depositing User: |
Matt Covey
|
| Date: |
2001 |
| Date Deposited: |
09 Jan 2013 16:55 |
| Last Modified: |
19 Sep 2014 13:52 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/26472 |
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