Van Aelst, L., White, M., Wigler, M. H. (1994) Ras partners. Cold Spring Harbor Symposia on Quantitative Biology, 59. pp. 181-186. ISSN 00917451 (ISSN)
Abstract
The RAS oncogenes were first discovered as the transforming elements of acutely oncogenic retroviruses. Subsequently, cellular RAS genes were found to be frequently activated by mutation in a wide variety of human cancers, providing the first example of a common oncogenic mechanism. As a consequence, Ras proteins have been studied extensively (for review, see Barbacid 1987). RAS genes are found ubiquitously in eukaryotic organisms. They encode low-molecular-weight guanine nucleotide-binding proteins that hydrolyze GTP and localize to the inner surface of the plasma membrane after undergoing elaborate carboxy-terminal processing. Proteins that are involved in processing Ras, or in regulating its activity, e.g., by accelerating guanine nucleotide hydrolysis or exchange, have been largely conserved in evolution (for review, see Wigler 1993).
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Binding Sites Genes ras Humans Mutation Protein Binding Protein Serine Threonine Kinases metabolism Proto-Oncogene Proteins metabolism proto oncogene Proto-Oncogene Proteins c-raf Saccharomyces cerevisiae genetics metabolism Schizosaccharomyces genetics metabolism Transfection ras Proteins genetics metabolism |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > RAS bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene |
| CSHL Authors: | |
| Communities: | CSHL labs > Van Aelst lab CSHL labs > Wigler lab |
| Depositing User: | CSHL Librarian |
| Date: | 1994 |
| Date Deposited: | 11 Apr 2012 20:51 |
| Last Modified: | 22 Feb 2017 22:01 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/26240 |
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