Mu, D., Chen, L. Y., Zhang, X. P., See, L. H., Koch, C. M., Yen, C., Tong, J. J., Spiegel, L., Nguyen, K. C. Q., Servoss, A., Peng, Y., Pei, L., Marks, J. R., Lowe, S. W., Hoey, T., Jan, L. Y., McCombie, W. R., Wigler, M. H., Powers, S. (March 2003) Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell, 3 (3). pp. 297-302. ISSN 1535-6108
Abstract
Representational difference analysis (RDA) of human breast cancer was used to discover a novel amplicon located at chromosomal region 8q24.3. We examined a series of breast cancer samples harboring amplification of this region and determined that KCNK9 is the sole overexpressed gene within the amplification epicenter. KCNK9 encodes a potassium channel that is amplified from 3-fold to 10-fold in 10% of breast tumors and overexpressed from 5-fold to over 100-fold in 44% of breast tumors. Overexpression of KCNK9 in cell lines promotes tumor formation and confers resistance to both hypoxia and serum deprivation, suggesting that its amplification and overexpression plays a physiologically important role in human breast cancer.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | K+ CHANNEL channel TUMORS tumors HYBRIDIZATION hybridization PREDICTION prediction CLONING cloning TASK-3 Task-3 FAMILY family |
| Subjects: | diseases & disorders > cancer > cancer types > breast cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene amplification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression |
| CSHL Authors: | |
| Communities: | CSHL labs > Lowe lab CSHL labs > McCombie lab CSHL labs > Powers lab CSHL labs > Wigler lab |
| Depositing User: | CSHL Librarian |
| Date: | March 2003 |
| Date Deposited: | 12 Apr 2012 13:54 |
| Last Modified: | 11 Apr 2013 20:09 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/26233 |
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