Taparowsky, E., Shimizu, K., Goldfarb, M., Wigler, M. H. (1983) Structure and Activation of the Human N-Ras Gene. Cell, 34 (2). pp. 581-586.
Abstract
The normal human N-ras gene was cloned. In structure and sequence it closely resembles the human H-ras and K-ras genes. The 3 genes share regions of nucleotide homology and nucleotide divergence within coding sequences and have a common intron/exon structure, indicating that they evolved from a similarly spliced ancestral gene. The N-ras gene of SK-N-SH neuroblastoma cells has transforming activity, while the normal N-ras gene does not, the result of a single nucleotide change substituting Lys for Gln in position 61 of the N-ras gene product. Amino acid substitutions in 2 distinct regions can activate the transforming potential of ras gene products.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > RAS bioinformatics > genomics and proteomics > annotation > sequence annotation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression organism description > animal > mammal > primates > hominids > human bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene |
| CSHL Authors: | |
| Communities: | CSHL labs > Wigler lab |
| Depositing User: | CSHL Librarian |
| Date: | 1983 |
| Date Deposited: | 06 Apr 2012 13:48 |
| Last Modified: | 18 Nov 2016 16:50 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/26003 |
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