Xu, H. P., Wang, Y., Riggs, M., Rodgers, L., Wigler, M. H. (September 1990) Biological activity of the mammalian RAP genes in yeast. Cell Regulation, 1 (10). pp. 763-769. ISSN 1044-2030
Abstract
We have screened expression libraries for mammalian cDNAs capable of suppressing defects in ras1- Schizosaccharomyces pombe. Both the RAP1A and RAP1B genes were identified in this manner. They suppress defects in cell morphology and sporulation, although not conjugation. In contrast, RAP genes do not suppress phenotypes in the yeast Saccharomyces cerevisiae that are deficient in RAS. Indeed, expression of RAP1A appears to antagonize the activated S. cerevisiae RAS2val19 gene. These results indicate that RAP proteins can interact with RAS targets, sometimes productively, sometimes nonproductively.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > RAS bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression |
| CSHL Authors: | |
| Communities: | CSHL labs > Stillman lab CSHL labs > Wigler lab |
| Depositing User: | CSHL Librarian |
| Date: | September 1990 |
| Date Deposited: | 06 Apr 2012 18:42 |
| Last Modified: | 27 Feb 2017 14:59 |
| PMCID: | PMC361659 |
| URI: | https://repository.cshl.edu/id/eprint/25948 |
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