Guo, X. C., Mills, A. A.
(February 2007)
p63, cellular senescence and tumor development.
Cell Cycle, 6 (3).
pp. 305-11.
ISSN 1538-4101
Abstract
Deficiency of p63, a p53-related protein, causes severe defects in epithelial morphogenesis. Studies of p63-compromised mouse models reveal that p63 deficiency induces cellular senescence both in cultured cells and in vivo, through regulation p19(Arf)/p53 and p16(Ink4a)/Rb pathways. An extensive tumor study of p63-compromised mice demonstrated that p63 deficiency does not predispose to, but rather protects from, tumor development. These findings further implicate p63 as a negative regulator of the tumor suppressive mechanism of cellular senescence.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
p63
senescence
tumorigenesis
oncogene
tumor suppressor
animal model
P53-FAMILY MEMBERS P63
P53 TARGET GENES
DIFFERENTIAL REGULATION
ONCOGENIC RAS
IN-VIVO
TRANSCRIPTIONAL ACTIVITY
P53-DEPENDENT
APOPTOSIS
REPLICATIVE SENESCENCE
PREMATURE SENESCENCE
NUCLEAR
ACCUMULATION |
| Subjects: |
diseases & disorders > cancer
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
organism description > animal > mammal > rodent > mouse
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p53
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p63
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > senescence |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Mills lab |
| Depositing User: |
CSHL Librarian
|
| Date: |
February 2007 |
| Date Deposited: |
15 Nov 2011 14:28 |
| Last Modified: |
02 Feb 2017 17:06 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/23022 |
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