Wiring optimization can relate neuronal structure and function

Chen, B. L., Hall, D. H., Chklovskii, D. B. (March 2006) Wiring optimization can relate neuronal structure and function. Proc Natl Acad Sci U S A, 103 (12). pp. 4723-8. ISSN 0027-8424 (Print)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/16537428

DOI: 10.1073/pnas.0506806103

Abstract

We pursue the hypothesis that neuronal placement in animals minimizes wiring costs for given functional constraints, as specified by synaptic connectivity. Using a newly compiled version of the Caenorhabditis elegans wiring diagram, we solve for the optimal layout of 279 nonpharyngeal neurons. In the optimal layout, most neurons are located close to their actual positions, suggesting that wiring minimization is an important factor. Yet some neurons exhibit strong deviations from "optimal" position. We propose that biological factors relating to axonal guidance and command neuron functions contribute to these deviations. We capture these factors by proposing a modified wiring cost function.

Item Type:	Paper
Uncontrolled Keywords:	Animals Caenorhabditis elegans cytology physiology Models Neurological Neurons cytology physiology ultrastructure Synapses physiology
Subjects:	organism description > animal > C elegans bioinformatics > quantitative biology bioinformatics > genomics and proteomics > Mapping and Rendering > Structure Rendering organs, tissues, organelles, cell types and functions > tissues types and functions > axon organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:	Chen, Beth L. Chklovskii, Dmitri B.
Communities:	CSHL labs > Chklovskii lab School of Biological Sciences > Publications
Depositing User:	CSHL Librarian
Date:	21 March 2006
Date Deposited:	19 Dec 2011 18:25
Last Modified:	09 Nov 2017 16:17
PMCID:	PMC1550972
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/22772

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