Chklovskii, D. B., Mel, B. W., Svoboda, K. (October 2004) Cortical rewiring and information storage. Nature, 431 (7010). pp. 782-788. ISSN 0028-0836
Abstract
Current thinking about long-term memory in the cortex is focused on changes in the strengths of connections between neurons. But ongoing structural plasticity in the adult brain, including synapse formation/elimination and remodelling of axons and dendrites, suggests that memory could also depend on learning-induced changes in the cortical 'wiring diagram'. Given that the cortex is sparsely connected, wiring plasticity could provide a substantial boost in storage capacity, although at a cost of more elaborate biological machinery and slower learning.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | RAT BARREL CORTEX rat barrel cortex IN-VIVO in-vivo PYRAMIDAL NEURONS pyramidal neurons VISUAL-CORTEX visual cortex DEPENDENT PLASTICITY plasticity SYNAPTIC PLASTICITY synaptic DENDRITIC SPINES dendritic spines SILENT SYNAPSES silent synapsis NMDA RECEPTOR nmda receptor GLUTAMATERGIC SYNAPSE glutamatergic synapse |
| Subjects: | organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex |
| CSHL Authors: | |
| Communities: | CSHL labs > Chklovskii lab CSHL labs > Svoboda lab |
| Depositing User: | CSHL Librarian |
| Date: | October 2004 |
| Date Deposited: | 09 Feb 2012 16:17 |
| Last Modified: | 18 Jan 2017 17:59 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/22352 |
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