Oviedo, H. V., Bureau, I., Svoboda, K., Zador, A. M. (October 2010) The functional asymmetry of auditory cortex is reflected in the organization of local cortical circuits. Nature Neuroscience, 13 (11). pp. 1413-1420. ISSN 1097-6256
Abstract
The primary auditory cortex (A1) is organized tonotopically, with neurons sensitive to high and low frequencies arranged in a rostro-caudal gradient. We used laser scanning photostimulation in acute slices to study the organization of local excitatory connections onto layers 2 and 3 (L2/3) of the mouse A1. Consistent with the organization of other cortical regions, synaptic inputs along the isofrequency axis (orthogonal to the tonotopic axis) arose predominantly within a column. By contrast, we found that local connections along the tonotopic axis differed from those along the isofrequency axis: some input pathways to L3 (but not L2) arose predominantly out-of-column. In vivo cell-attached recordings revealed differences between the sound-responsiveness of neurons in L2 and L3. Our results are consistent with the hypothesis that auditory cortical microcircuitry is specialized to the one-dimensional representation of frequency in the auditory cortex.
| Item Type: | Paper |
|---|---|
| Subjects: | organism description > animal behavior > auditory organism description > animal > mammal > rodent > mouse |
| CSHL Authors: | |
| Communities: | CSHL Post Doctoral Fellows CSHL labs > Svoboda lab CSHL labs > Zador lab |
| Depositing User: | CSHL Librarian |
| Date: | 17 October 2010 |
| Date Deposited: | 05 Oct 2011 14:34 |
| Last Modified: | 02 May 2013 21:02 |
| PMCID: | PMC3140463 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/15501 |
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