Items where Subject is "RAS"

Paper

Andersen, L. B., Ballester, R., Marchuk, D. A., Chang, E., Gutmann, D. H., Saulino, A. M., Camonis, J., Wigler, M. H., Collins, F. S. (January 1993) A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity. Molecular and Cellular Biology, 13 (1). pp. 487-495. ISSN 0270-7306

Ballester, R., Marchuk, D., Boguski, M., Saulino, A., Letcher, R., Wigler, M. H., Collins, F. (November 1990) The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell, 63 (4). pp. 851-9. ISSN 0092-8674

Ballester, R., Michaeli, T., Ferguson, K., Xu, H. P., McCormick, F., Wigler, M. H. (November 1989) Genetic analysis of mammalian GAP expressed in yeast. Cell, 59 (4). pp. 681-6. ISSN 0092-8674

Ballester, R., Wigler, M. H. (1990) Isolation and Characterization of Genes That Regulate Ras Function in the Yeast Saccharomyces-Cerevisiae. Yeast, 6 (SPEC. ). S212.

Barker, D., McCoy, M., Weinberg, R., Goldfarb, M., Wigler, M. H., Burt, R., Gardner, E., White, R. (September 1983) A test of the role of two oncogenes in inherited predisposition to colon cancer. Mol Biol Med, 1 (2). pp. 199-206. ISSN 0735-1313 (Print)

Bihani, Teeru, Chicas, Agustin, Lo, Crystal Pui-Kwan, Lin, Athena W. (January 2007) Dissecting the senescence-like program in tumor cells activated by Ras signaling. Journal of Biological Chemistry, 282 (4). pp. 2666-2675. ISSN 0021-9258

Birchmeier, C., Broek, D., Toda, T., Powers, S., Kataoka, T., Wigler, M. H. (1985) Conservation and divergence of RAS protein function during evolution. Cold Spring Harbor Symposia on Quantitative Biology, 50. pp. 721-725. ISSN 00917451 (ISSN)

Birchmeier, C., Broek, D., Wigler, M. H. (December 1985) RAS proteins can induce meiosis in Xenopus oocytes. Cell, 43 (3 PART). pp. 615-622.

Broach, J., Toda, T., Kataoka, T., Powers, S., Broek, D., Wigler, M. H. (1985) Ras Proteins Function Exclusively to Modulate Adenylate-Cyclase Activity in the Yeast Saccharomyces. DNA-a Journal of Molecular & Cellular Biology, 4 (1). p. 64. ISSN 0198-0238

Broek, D., Samily, N., Fasano, O., Fujiyama, A., Tamanoi, F., Northup, J., Wigler, M. H. (1985) Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteins. Cell, 41 (3). pp. 763-770.

Broek, D., Toda, T., Michaeli, T., Levin, L., Birchmeier, C., Zoller, M., Powers, S., Wigler, M. H. (March 1987) The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway. Cell, 48 (5). pp. 789-800.

Cameron, S., Levin, L., Zoller, M., Wigler, M. H. (May 1988) cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae. Cell, 53 (4). pp. 555-66. ISSN 0092-8674

Chang, E. C., Barr, M., Wang, Y., Jung, V., Xu, H. P., Wigler, M. H. (October 1994) Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell, 79 (1). pp. 131-41. ISSN 0092-8674 (Print)

Chardin, P., Camonis, J. H., Gale, N. W., van Aelst, L., Schlessinger, J., Wigler, M. H., Bar-Sagi, D. (May 1993) Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science, 260 (5112). pp. 1338-1343.

Colicelli, J., Birchmeier, C., Michaeli, T., O'Neill, K., Riggs, M., Wigler, M. H. (May 1989) Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase. Proc Natl Acad Sci U S A, 86 (10). pp. 3599-603. ISSN 0027-8424

Colicelli, J., Field, J., Ballester, R., Chester, N., Young, D., Wigler, M. H. (June 1990) Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase. Molecular & Cellular Biology, 10 (6). pp. 2539-43. ISSN 0270-7306

Colicelli, J., Nicolette, C., Birchmeier, C., Rodgers, L., Riggs, M., Wigler, M. H. (April 1991) Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A, 88 (7). pp. 2913-7. ISSN 0027-8424

Daar, I., Nebreda, A. R., Yew, N., Sass, P., Paules, R., Santos, E., Wigler, M. H., Vandewoude, G. F. (July 1991) The Ras Oncoprotein and M-Phase Activity. Science, 253 (5015). pp. 74-76. ISSN 0036-8075

Dong, D. L., Liu, R., Sherlock, R., Wigler, M. H., Nestler, H. P. (March 1999) Molecular forceps from combinatorial libraries prevent the farnesylation of Ras by binding to its carboxyl terminus. Chem Biol, 6 (3). pp. 133-41. ISSN 1074-5521 (Print)

Fasano, O., Aldrich, T., Tamanoi, F., Taparowsky, E., Furth, M., Wigler, M. H. (1984) Analysis of the transforming potential of the human H-ras gene by random mutagenesis. Proceedings of the National Academy of Sciences of the United States of America, 81 (13). pp. 4008-4012.

Fasano, O., Taparowsky, E., Fiddes, J., Wigler, M. H., Goldfarb, M. (1983) Sequence and Structure of the Coding Regions of the Human H-Ras-1 Gene from T-24 Bladder Carcinoma Cells. Journal of Molecular & Applied Genetics, 2 (2). pp. 173-180. ISSN 0271-6801

Feramisco, J., Sullivan, N., Kamata, T., Barsagi, D., Welch, W., Gross, M., Sweet, R., Rosenberg, M., Sathe, G., Fasano, O., Goldfarb, M., Wigler, M. H., Nitecki, D., Clark, R., Arnheim, N., McCormick, F. (1985) Microinjection of Ras Oncogene Proteins and Inhibitory Antibodies Specific for the Ras Oncogene Proteins into Living Normal and Transformed-Cells. Federation Proceedings, 44 (5). p. 1768. ISSN 0014-9446

Field, J., Broek, D., Kataoka, T., Wigler, M. H. (1987) Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae. Molecular & Cellular Biology, 7 (6). pp. 2128-2133.

Field, J., Colicelli, J., Vojtek, A., Ballester, R., Ferguson, K., Chester, N., Michaeli, T., Gerst, J., Riggs, M. (1990) Ras from the Yeast Perspective. Journal of Cellular Biochemistry, 44 (S14C). p. 124.

Field, J., Nikawa, J., Broek, D., MacDonald, B., Rodgers, L., Wilson, I. A., Lerner, R. A., Wigler, M. H. (May 1988) Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Molecular & Cellular Biology, 8 (5). pp. 2159-65. ISSN 0270-7306

Field, J., Xu, H. P., Michaeli, T., Ballester, R., Sass, P., Wigler, M. H., Colicelli, J. (January 1990) Mutations of the adenylyl cyclase gene that block RAS function in Saccharomyces cerevisiae. Science, 247 (4941). pp. 464-7. ISSN 0036-8075

Gerst, J. E., Field, J., Ferguson, K., Wigler, M. H. (1990) Molecular and Phenotypic Analysis of Cap a Regulatory Element Involved in Mediating Both Ras Action and Amino Acid Balance. Yeast, 6 (SPEC. ). S174.

Gerst, J. E., Rodgers, L., Riggs, M., Wigler, M. (May 1992) SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes. Proc Natl Acad Sci U S A, 89 (10). pp. 4338-42. ISSN 0027-8424 (Print)0027-8424 (Linking)

Gross, M., Sweet, R. W., Sathe, G., Yokoyama, S., Fasano, O., Goldfarb, M., Wigler, M. H., Rosenberg, M. (1985) Purification and characterization of human H-RAS proteins expressed in Escherichia coli. Molecular and Cellular Biology, 5 (5). pp. 1015-1024. ISSN 0270-7306

Gutmann, D. H., Boguski, M., Marchuk, D., Wigler, M. H., Collins, F. S., Ballester, R. (March 1993) Analysis of the neurofibromatosis type-1 (NF1) GAP-related domain by site-directed mutagenesis. Oncogene, 8 (3). pp. 761-769. ISSN 0950-9232

Hannon, G. J., Sun, P., Carnero, A., Xie, L. Y., Maestro, R., Conklin, D. S., Beach, D. (February 1999) MaRX: an approach to genetics in mammalian cells. Science, 283 (5405). pp. 1129-30. ISSN 0036-8075

Herlands, L., Kishimoto, T., Birchmeier, C., Wigler, M. H., Koide, S. S. (December 1986) Induction of Oocyte Maturation by Injection of Oncogenic H-Ras Protein in the Starfish. Zoological Science, 3 (6). p. 1036. ISSN 0289-0003

Joneson, T., White, M. A., Wigler, M. H., Bar-Sagi, D. (February 1996) Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science, 271 (5250). pp. 810-812. ISSN 0036-8075

Jung, V., Chen, L., Hofmann, S. L., Wigler, M. H., Powers, S. (March 1995) Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins. Mol Cell Biol, 15 (3). pp. 1333-42. ISSN 0270-7306 (Print)

Jung, V., Wei, W., Ballester, R., Camonis, J., Mi, S., Van Aelst, L., Wigler, M. H., Broek, D. (June 1994) Two types of RAS mutants that dominantly interfere with activators of RAS. Mol Cell Biol, 14 (6). pp. 3707-18. ISSN 0270-7306 (Print)

Kataoka, T., Powers, S., Cameron, S., Fasano, O., Goldfarb, M., Broach, J., Wigler, M. H. (1985) Functional homology of mammalian and yeast RAS genes. Cell, 40 (1). pp. 19-26.

Kataoka, T., Powers, S., McGill, C., Fasano, O., Strathern, J., Broach, J., Wigler, M. H. (June 1984) Genetic analysis of yeast RAS1 and RAS2 genes. Cell, 37 (2). pp. 437-445. ISSN 0092-8674

Khosravi-Far, R., White, M. A., Westwick, J. K., Solski, P. A., Chrzanowska-Wodnicka, M., Van Aelst, L., Wigler, M. H., Der, C. J. (July 1996) Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol, 16 (7). pp. 3923-33. ISSN 0270-7306 (Print)

Liu, R., Dong, D. L., Sherlock, R., Nestler, H. P., Gennari, C., Mielgo, A., Scolastico, C. (March 1999) Novel reverse-turn mimics inhibit farnesyl transferase. Bioorganic and Medicinal Chemistry Letters , 9 (6). pp. 847-52. ISSN 0960-894X (Print)

Marcus, S., Polverino, A., Chang, E., Robbins, D., Cobb, M. H., Wigler, M. H. (June 1995) Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proc Natl Acad Sci U S A, 92 (13). pp. 6180-4. ISSN 0027-8424 (Print)

Marcus, S., Wigler, M. H., Xu, H. P., Ballester, R., Kawamukai, M., Polverino, A. (1993) RAS function and protein kinase cascades. Ciba Found Symp, 176. 53-61; discussion 61. ISSN 0300-5208 (Print)

Michaeli, T., Field, J., Ballester, R., O'Neill, K., Wigler, M. H. (October 1989) Mutants of H-ras that interfere with RAS effector function in Saccharomyces cerevisiae. Embo J, 8 (10). pp. 3039-44. ISSN 0261-4189

Michaelis, S., Anna, S. S., Powers, S., Wigler, M. H., Herskowitz, I. (1987) Yeast Mating Pheromone a-Factor and Its Relationship to Ras Proteins. Journal of Cellular Biochemistry. p. 261. ISSN 0730-2312

Powers, S., Kataoka, T., Fasano, O., Goldfarb, M., Strathern, J., Broach, J., Wigler, M. H. (March 1984) Genes in Saccharomyces cerevisiae encoding proteins with domains homologous to the mammalian ras proteins. Cell, 36 (3). pp. 607-612.

Powers, S., Kataoka, T., Toda, T., Fasano, O., Wigler, M. H. (1985) Control of Yeast Adenyl-Cyclase by Ras Proteins. Federation Proceedings, 44 (3). R8-R8. ISSN 0014-9446

Powers, S., Michaelis, S., Broek, D., Ann-A, S. S., Field, J., Herskowitz, I., Wigler, M. H. (1986) RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor. Cell, 47 (3). pp. 413-422.

Powers, S., O'Neill, K., Wigler, M. H. (February 1989) Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae. Molecular & Cellular Biology, 9 (2). pp. 390-5. ISSN 0270-7306

Rodriguez-Viciana, P., Warne, P. H., Khwaja, A., Marte, B. M., Pappin, D., Das, P., Waterfield, M. D., Ridley, A., Downward, J. (May 1997) Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell, 89 (3). pp. 457-67. ISSN 0092-8674 (Print)0092-8674 (Linking)

Sass, P., Field, J., Nikawa, J., Toda, T., Wigler, M. H. (1986) Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America, 83 (24). pp. 9303-9307.

Shibuya, E. K., Polverino, A. J., Chang, E., Wigler, M. H., Ruderman, J. V. (October 1992) Oncogenic Ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America, 89 (20). pp. 9831-9835. ISSN 0027-8424

Shimizu, K., Birnbaum, D., Ruley, M. A., Fasano, O., Suard, Y., Edlund, L., Taparowsky, E., Goldfarb, M., Wigler, M. H. (August 1983) Structure of the Ki-Ras Gene of the Human-Lung Carcinoma Cell-Line Calu-1. Nature, 304 (5926). pp. 497-500. ISSN 0028-0836

Shimizu, K., Goldfarb, M., Perucho, M., Wigler, M. H. (January 1983) Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc Natl Acad Sci U S A, 80 (2). pp. 383-387.

Shimizu, K., Goldfarb, M., Suard, Y., Perucho, M., Li, Y., Kamata, T., Feramisco, J., Stavnezer, E., Fogh, J., Wigler, M. H. (April 1983) Three human transforming genes are related to the viral ras oncogenes. Proceedings of the National Academy of Sciences of the United States of America, 80 (8). pp. 2112-2116. ISSN 0027-8424

Shimizu, K., Taparowsky, E., Fasano, O., Suard, Y., Birnbaum, D., Ruley, M. A., Goldfarb, M., Wigler, M. H. (1983) Structures of 3 Ras Genes Activated in Human-Tumor Cell-Lines. Journal of Cell Biology, 97 (5). A69-A69. ISSN 0021-9525

Silva, A. J., Elgersma, Y., Friedman, E., Stern, J., Kogan, J. (November 1998) A mouse model for learning and memory defects associated with neurofibromatosis type I. Pathol Biol (Paris), 46 (9). pp. 697-8. ISSN 0369-8114 (Print)

Tamanoi, F., Walsh, M., Kataoka, T., Wigler, M. H. (1984) A product of yeast RAS-2 gene is a guanine nucleotide binding protein. Proceedings of the National Academy of Sciences of the United States of America, 81 (22). pp. 6924-6928.

Taparowsky, E., Shimizu, K., Goldfarb, M., Wigler, M. H. (1983) Structure and Activation of the Human N-Ras Gene. Cell, 34 (2). pp. 581-586.

Toda, T., Uno, I., Ishikawa, T., Powers, S., Kataoka, T., Broek, D., Cameron, S., Broach, J., Matsumoto, K., Wigler, M. H. (1985) In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell, 40 (1). pp. 27-36.

Van Aelst, L. (1998) Two-hybrid analysis of Ras-Raf interactions. Methods in Molecular Biology, 84. pp. 201-22. ISSN 1064-3745 (Print)

Van Aelst, L., Barr, M., Marcus, S., Polverino, A., Wigler, M. H. (July 1993) Complex formation between RAS and RAF and other protein kinases. Proc Natl Acad Sci U S A, 90 (13). pp. 6213-7. ISSN 0027-8424 (Print)

Van Aelst, L., White, M., Wigler, M. H. (1994) Ras partners. Cold Spring Harbor Symposia on Quantitative Biology, 59. pp. 181-186. ISSN 00917451 (ISSN)

Vojtek, A., Field, J., Gerst, J., Wigler, M. H. (1991) The Ras Signalling Pathway in Yeast. Journal of Cellular Biochemistry - Supplement.(15 PART B). p. 84.

Wang, Y., Boguski, M., Riggs, M., Rodgers, L., Wigler, M. (1991) sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1. Cell Regulation, 2 (6). pp. 453-465. ISSN 10442030 (ISSN)

Wang, Y., Xu, H. P., Riggs, M., Rodgers, L., Wigler, M. H. (July 1991) byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype. Molecular & Cellular Biology, 11 (7). pp. 3554-63. ISSN 0270-7306

Webb, C. P., Van Aelst, L., Wigler, M. H., Woude, G. F. (July 1998) Signaling pathways in Ras-mediated tumorigenicity and metastasis. Proc Natl Acad Sci U S A, 95 (15). pp. 8773-8. ISSN 0027-8424 (Print)

White, M. A., Nicolette, C., Minden, A., Polverino, A., Van Aelst, L., Karin, M., Wigler, M. H. (February 1995) Multiple Ras functions can contribute to mammalian cell transformation. Cell, 80 (4). pp. 533-41. ISSN 0092-8674 (Print)

White, M. A., Vale, T., Camonis, J. H., Schaefer, E., Wigler, M. H. (July 1996) A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation. J Biol Chem, 271 (28). pp. 16439-42. ISSN 0021-9258 (Print)

Wigler, M. H. (August 1990) Oncoproteins. Gaps in Understanding Ras. Nature, 346 (6286). pp. 696-697. ISSN 0028-0836

Wigler, M. H., Ballester, R., Chang, E., Colicelli, J., Field, J., Gerst, J., Kawamukai, M., Michaeli, T., Nicolette, C. (1991) The Ways of Ras. Proceedings American Association for Cancer Research Annual Meeting. p. 435.

Wigler, M. H., Cameron, S., Powers, S., Field, J., Toda, T., Broek, D., Nikawa, J., Michaelis, T., Colicelli, J. (1988) Integration of Ras and Adenylate Cyclase Pathways in Yeast. Journal of Cell Biology, 107 (6 PART). 4A.

Wigler, M. H., Field, J., Powers, S., Broek, D., Toda, T., Cameron, S., Nikawa, J., Michaeli, T., Colicelli, J., Ferguson, K. (1988) Studies of RAS function in the yeast Saccharomyces cerevisiae. Cold Spring Harbor Symposia on Quantitative Biology, 53 (2). pp. 649-55. ISSN 00917451 (ISSN)

Wigler, M. H., Xu, H. P., Vanaelst, L., Jung, V., Marcus, S., Polverino, T., Oneill, K., Chang, E., Camonis, J., Nicolette, C., White, M., Ballester, R. (April 1993) Evolution of Ras Signal Transduction Pathways. Faseb Journal, 7 (7). A1124-A1124. ISSN 0892-6638

Xu, H. P., Wang, Y., Riggs, M., Rodgers, L., Wigler, M. H. (September 1990) Biological activity of the mammalian RAP genes in yeast. Cell Regulation, 1 (10). pp. 763-769. ISSN 1044-2030

Xu, H. P., White, M., Marcus, S., Wigler, M. H. (January 1994) Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe. Mol Cell Biol, 14 (1). pp. 50-8. ISSN 0270-7306 (Print)

Book Section

Taparowsky, E., Suard, Y., Fasano, O., Shimizu, K., Goldfarb, M., Wigler, M. H. (1983) Activation of the Human H-Ras Gene. In: Recombinant DNA applications to human disease. Banbury report, 14 (ED.). Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp. 123-134. ISBN 0879692146

Toda, T., Broek, D., Field, J., Michaeli, T., Cameron, S., Nikawa, J., Sass, P., Birchmeier, C., Powers, S., Wigler, M. H. (1987) Exploring the function of RAS oncogenes by studying the yeast Saccharomyces cerevisiae. In: Oncogenes and cancer : proceedings of the 17th International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo, 1986. Princess Takamatsu Symposia , 17 . Japan Scientific Societies Press, Tokyo, pp. 253-260. ISBN 4762205176

Wigler, M. H., Fasano, O., Taparowsky, E., Powers, S., Kataoka, T., Birnbaum, D., Shimizu, K., Goldfarb, M. (1984) Structure and Activation of Ras Genes. In: Oncogenes and viral genes. Cancer cells, 2 (ED.). Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp. 419-424. ISBN 0879691697

Wigler, M. H., Powers, S., Kataoka, T., Toda, T., Fasano, O., Matsumoto, K., Uno, I., Ishikawa, T., Broach, J. (1985) Function of Yeast Ras Genes. In: Genetics, cell differentiation, and cancer. Bristol-Myers cancer symposia, 7 (ED.). Academic Press, Orlando, pp. 153-164.