Browse by CSHL Author

Li, Jiayun, Moresco, Philip, Fearon, Douglas T (July 2024) Intratumoral NKT cell accumulation promotes antitumor immunity in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 121 (29). e2403917121. ISSN 0027-8424 (Public Dataset)

Maia-Silva, Diogo, Cunniff, Patrick J, Schier, Allison C, Skopelitis, Damianos, Trousdell, Marygrace C, Moresco, Philip, Gao, Yuan, Kechejian, Vahag, He, Xue-Yan, Sahin, Yunus, Wan, Ledong, Alpsoy, Aktan, Liverpool, Jynelle, Krainer, Adrian R, Egeblad, Mikala, Spector, David L, Fearon, Douglas T, Dos Santos, Camila O, Taatjes, Dylan J, Vakoc, Christopher R (June 2024) Interaction between MED12 and ΔNp63 activates basal identity in pancreatic ductal adenocarcinoma. Nature Genetics. ISSN 1061-4036

Yao, Min, Preall, Jonathan, Yeh, Johannes, Pappin, Darryl J, Cifani, Paolo, Zhao, Yixin, Shen, Sophia, Moresco, Philip, He, Brian, Patel, Hardik, Habowski, Amber N, King, Daniel A, Raphael, Kara L, Rishi, Arvind, Sejpal, Divyesh V, Weiss, Matthew, Tuveson, David, Fearon, Douglas T (September 2023) Plasma cells in human pancreatic ductal adenocarcinoma secrete antibodies to self-antigens. JCI Insight. e172449. ISSN 2379-3708 (Public Dataset)

Yan, Ran, Moresco, Philip, Gegenhuber, Bruno, Fearon, Douglas T (June 2023) T cell-Mediated Development of Stromal Fibroblasts with an Immune-Enhancing Chemokine Profile. Cancer Immunology Research. OF1-OF11. ISSN 2326-6066

Wang, Zhikai, Moresco, Philip, Yan, Ran, Li, Jiayun, Gao, Ya, Biasci, Daniele, Yao, Min, Pearson, Jordan, Hechtman, Jaclyn F, Janowitz, Tobias, Zaidi, Raza M, Weiss, Matthew J, Fearon, Douglas T (January 2022) Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack. Proceedings of the National Academy of Sciences of USA, 119 (4). e2119463119-e2119463119. ISSN 0027-8424

Roberts, EW, Denton, AE, Fearon, DT (January 2022) Roles of Stromal Cells in the Immune System. In: Encyclopedia of Cell Biology: Volume 1-6, Second Edition. UNSPECIFIED, pp. 484-492. ISBN 9780128216248

Fearon, Douglas T, Janowitz, Tobias (March 2021) AMD3100/Plerixafor overcomes immune inhibition by the CXCL12-KRT19 coating on pancreatic and colorectal cancer cells. British Journal of Cancer. ISSN 0007-0920

Biasci, D., Smoragiewicz, M., Connell, C. M., Wang, Z., Gao, Y., Thaventhiran, J. E. D., Basu, B., Magiera, L., Johnson, T. I., Bax, L., Gopinathan, A., Isherwood, C., Gallagher, F. A., Pawula, M., Hudecova, I., Gale, D., Rosenfeld, N., Barmpounakis, P., Popa, E. C., Brais, R., Godfrey, E., Mir, F., Richards, F. M., Fearon, D. T., Janowitz, T., Jodrell, D. I. (November 2020) CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response. Proc Natl Acad Sci U S A, 117 (46). pp. 28960-28970. ISSN 0027-8424 (Print)0027-8424

Fein, Miriam R, He, Xue-Yan, Almeida, Ana S, Bružas, Emilis, Pommier, Arnaud, Yan, Ran, Eberhardt, Anaïs, Fearon, Douglas T, Van Aelst, Linda, Wilkinson, John Erby, Dos Santos, Camila O, Egeblad, Mikala (October 2020) Cancer cell CCR2 orchestrates suppression of the adaptive immune response. Journal of Experimental Medicine, 217 (10). ISSN 0022-1007

Wang, Zhikai, Yan, Ran, Li, Jiayun, Gao, Ya, Moresco, Philip, Yao, Min, Hechtman, Jaclyn F, Weiss, Matthew J, Janowitz, Tobias, Fearon, Douglas T (September 2020) Pancreatic cancer cells assemble a CXCL12-keratin 19 coating to resist immunotherapy. bioRxiv. (Unpublished)

Fearon, Douglas, Wang, Zhikai (September 2020) Pancreatic cancer cells assemble a CXCL12-keratin 19 coating to resist immunotherapy. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2020.

Biasci, D., Smoragiewicz, M., Connell, C. M., Wang, Z., Gao, Y., Thaventhiran, J. E., Basu, B., Magiera, L., Johnson, I. T., Bax, L., Gopinathan, A., Isherwood, C., Gallagher, F., Pawula, M., Hudecova, I., Gale, D., Rosenfeld, N., Barmpounakis, P., Popa, E. C., Brais, R., Godfrey, E., Mir, F., Richards, F., Fearon, D. T., Janowitz, T., Jodrell, D. (July 2020) CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response. medRxiv. (Unpublished)

Li, Jiayun, Wang, Zhikai, Fearon, Douglas T (May 2020) D40 signaling induces type I interferon and immune control in mouse pancreatic cancer lacking the CXCL12-coat. In: UNSPECIFIED. (Unpublished)

Yan, Ran, Wang, Zhikai, Gao, Ya, Janowitz, Tobias, Fearon, Douglas T (May 2020) Immunogenicity and the CXCL12-coat control T cell accumulation in murine pancreatic cancer. In: UNSPECIFIED. (Unpublished)

Yamamoto, K., Venida, A., Yano, J., Biancur, D.E., Kakiuchi, M., Gupta, S., Sohn, A.S.W., Mukhopadhyay, S., Lin, E.Y., Parker, S.J., Banh, R.S., Paulo, J.A., Wen, K.W., Debnath, J., Kim, G.E., Mancias, J.D., Fearon, D. T., Perera, R.M., Kimmelman, A.C. (May 2020) Autophagy Promotes Immune Evasion of Pancreatic Cancer by Degrading MHC-I. Nature, 581 (7806). pp. 100-105. ISSN 0028-0836

Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., Hynes, R. O., Jain, R. K., Janowitz, T., Jorgensen, C., Kimmelman, A. C., Kolonin, M. G., Maki, R. G., Powers, R. S., Pure, E., Ramirez, D. C., Scherz-Shouval, R., Sherman, M. H., Stewart, S., Tlsty, T. D., Tuveson, D. A., Watt, F. M., Weaver, V., Weeraratna, A. T., Werb, Z. (March 2020) A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer, 20 (3). pp. 174-186. ISSN 1474-175x

Denton, A. E., Carr, E. J., Magiera, L. P., Watts, A. J. B., Fearon, D. T. (July 2019) Embryonic FAP(+) lymphoid tissue organizer cells generate the reticular network of adult lymph nodes. J Exp Med, 216 (10). pp. 2242-2252. ISSN 0022-1007

Nayar, Saba, Campos, Joana, Smith, Charlotte G, Iannizzotto, Valentina, Gardner, David H, Mourcin, Frédéric, Roulois, David, Turner, Jason, Sylvestre, Marvin, Asam, Saba, Glaysher, Bridget, Bowman, Simon J, Fearon, Douglas T, Filer, Andrew, Tarte, Karin, Luther, Sanjiv A, Fisher, Benjamin A, Buckley, Christopher D, Coles, Mark C, Barone, Francesca (July 2019) Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology. Proceedings of the National Academy of Sciences of USA, 116 (27). pp. 13490-13497. ISSN 0027-8424

Croft, A. P., Campos, J., Jansen, K., Turner, J. D., Marshall, J., Attar, M., Savary, L., Wehmeyer, C., Naylor, A. J., Kemble, S., Begum, J., Durholz, K., Perlman, H., Barone, F., McGettrick, H. M., Fearon, D. T., Wei, K., Raychaudhuri, S., Korsunsky, I., Brenner, M. B., Coles, M., Sansom, S. N., Filer, A., Buckley, C. D. (May 2019) Distinct fibroblast subsets drive inflammation and damage in arthritis. Nature, 570 (7760). pp. 246-251. ISSN 0028-0836

Albrengues, J., Shields, M. A., Ng, D., Park, C. G., Ambrico, A., Poindexter, M. E., Upadhyay, P., Uyeminami, D. L., Pommier, A., Kuttner, V., Bruzas, E., Maiorino, L., Bautista, C., Carmona, E. M., Gimotty, P. A., Fearon, D. T., Chang, K., Lyons, S. K., Pinkerton, K. E., Trotman, L. C., Goldberg, M. S., Yeh, J. T., Egeblad, M. (September 2018) Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science, 361 (6409). ISSN 0036-8075

Fein, Miriam, He, Xue-Yan, Almeida, Ana, Bružas, Emilis, Pommier, Arnaud, Yan, Ran, Eberhardt, Anaïs, Fearon, Douglas, Van Aelst, Linda, Wilkinson, John, dos Santos, Camila, Egeblad, Mikala (August 2018) Cancer cell CCR2 orchestrates suppression of the adaptive immune response. bioRxiv.

Denton, A. E., Roberts, E. W., Fearon, D. T. (August 2018) Stromal Cells in the Tumor Microenvironment. In: Advances in Experimental Medicine and Biology. Springer International Publishing AG, pp. 99-114.

Pommier, A., Anaparthy, N., Memos, N., Kelley, Z. L., Gouronnec, A., Yan, R., Auffray, C., Albrengues, J., Egeblad, M., Iacobuzio-Donahue, C. A., Lyons, S. K., Fearon, D. T. (May 2018) Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases. Science, 360 (394). ISSN 0036-8075

Froeling, F., Tuveson, D. (May 2018) Pancreatic cancer foiled by a switch of tumour subtype. Nature, 557 (7706). pp. 500-501. ISSN 0028-0836

Binnewies, M., Roberts, E. W., Kersten, K., Chan, V., Fearon, D. F., Merad, M., Coussens, L. M., Gabrilovich, D. I., Ostrand-Rosenberg, S., Hedrick, C. C., Vonderheide, R. H., Pittet, M. J., Jain, R. K., Zou, W., Howcroft, T. K., Woodhouse, E. C., Weinberg, R. A., Krummel, M. F. (May 2018) Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat Med, 24 (5). pp. 541-550. ISSN 1078-8956

Goncalves, M. D., Hwang, S. K., Pauli, C., Murphy, C. J., Cheng, Z., Hopkins, B. D., Wu, D., Loughran, R. M., Emerling, B. M., Zhang, G., Fearon, D. T., Cantley, L. C. (January 2018) Fenofibrate prevents skeletal muscle loss in mice with lung cancer. Proc Natl Acad Sci U S A, 115 (4). E743-E752. ISSN 0027-8424

Connell, C. M., Raby, S. E. M., Beh, I., Flint, T. R., Williams, E. H., Fearon, D. T., Jodrell, D. I., Janowitz, T. (January 2018) Cancer Immunotherapy Trials Underutilize Immune Response Monitoring. Oncologist, 23 (1). pp. 116-117. ISSN 1083-7159

Balachandran, V. P., Luksza, M., Zhao, J. N., Makarov, V., Moral, J. A., Remark, R., Herbst, B., Askan, G., Bhanot, U., Senbabaoglu, Y., Wells, D. K., Cary, C. I. O., Grbovic-Huezo, O., Attiyeh, M., Medina, B., Zhang, J., Loo, J., Saglimbeni, J., Abu-Akeel, M., Zappasodi, R., Riaz, N., Smoragiewicz, M., Kelley, Z. L., Basturk, O., Gonen, M., Levine, A. J., Allen, P. J., Fearon, D. T., Merad, M., Gnjatic, S., Iacobuzio-Donahue, C. A., Wolchok, J. D., DeMatteo, R. P., Chan, T. A., Greenbaum, B. D., Merghoub, T., Leach, S. D. (November 2017) Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer. Nature, 551 (7681). pp. 512-516. ISSN 0028-0836

Balachandran, Vinod, Luksza, Marta, Zhao, Julia N, Makarov, Vladimir, Moral, John Alec, Remark, Romain, Herbst, Brian, Askan, Gokce, Bhanot, Umeshkumar, Senbabaoglu, Yasin, Wells, Danny, Cary, Charles Ian Ormsby, Grbovic-Huezo, Olivera, Attiyeh, Marc, Medina, Benjamin, Zhang, Jennifer, Loo, Jennifer, Saglimbeni, Joseph, Abu-Akeel, Mohsen, Zappasodi, Roberta, Riaz, Nadeem, Smoragiewicz, Martin, Basturk, Olca, Gonen, Mithat, Levine, Arnold J, Allen, Peter J, Fearon, Douglas T, Merad, Miriam, Gnjatic, Sacha, Iacobuzio-Donahue, Christine, Wolchok, Jedd, DeMatteo, Ronald, Greenbaum, Benjamin, Merghoub, Taha, Leach, Steven (November 2017) Identification of unique neoantigen qualities in long-term pancreatic cancer survivors. In: UNSPECIFIED.

Connell, C. M., Raby, S., Beh, I., Flint, T., Williams, E., Fearon, D. T., Jodrell, D. I., Janowitz, T. (July 2017) Cancer immunotherapy trial registrations increase exponentially but chronic immunosuppressive glucocorticoid therapy may compromise outcomes. Ann Oncol, 28 (7). pp. 1678-1679. ISSN 0923-7534

D'Rozario, J, Suliman, M, Knoblich, K, Roberts, D, De Campos, Dias J, Astarita, J, Dutton, E, Mansell, A, Denton, A, Fearon, D, Withers, D, Barone, F, Turley, S, Boyd, R, Heng, T, Fletcher, A (May 2017) Fibroblastic reticular cells facilitate myeloid cellular crosstalk via the provision of FRC derived growth and chemotactic factors. In: UNSPECIFIED.

Flint, Thomas R., Fearon, Douglas T., Janowitz, Tobias (May 2017) Connecting the Metabolic and Immune Responses to Cancer. Trends in Molecular Medicine, 23 (5). pp. 451-464. ISSN 1471-4914

Fearon, D. T. (April 2017) Explaining the Paucity of Intratumoral T Cells: A Construction Out of Known Entities. Cold Spring Harb Symp Quant Biol, 81. pp. 219-226. ISSN 0091-7451

Fearon, D. T. (March 2017) Immune-Suppressing Cellular Elements of the Tumor Microenvironment. Annual Review of Cancer Biology, 1 (1). pp. 241-255. ISSN 2472-3428

Ohlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., Chio, II, Hwang, C. I., Tiriac, H., Baker, L. A., Engle, D. D., Feig, C., Kultti, A., Egeblad, M., Fearon, D. T., Crawford, J. M., Clevers, H., Park, Y., Tuveson, D. A. (March 2017) Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J Exp Med, 214 (3). pp. 579-596. ISSN 0022-1007

Pommier, Arnaud, Anaparthy, Naishitha, Memos, Nicoletta, Kelley, Larkin, Gouronnec, Alizée, Albrengues, Jean, Egeblad, Mikala, Iacobuzio-Donahue, Christine, Lyons, Scott, Fearon, Douglas (2017) Endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases. Science. (Submitted)

Flint, T. R., Janowitz, T., Connell, C. M., Roberts, E. W., Denton, A. E., Coll, A. P., Jodrell, D. I., Fearon, D. T. (November 2016) Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity. Cell Metab, 24 (5). pp. 672-684. ISSN 1932-7420 (Electronic)1550-4131 (Linking)

D'Rozario, J., Knoblich, K., Roberts, D., De Campos, J. D., Astarita, J., Mansell, A., Denton, A., Fearon, D., Withers, D., Barone, F., Turley, S., Boyd, R. L., Heng, T., Fletcher, A. L. (August 2016) Human and murine fibroblastic reticular cells play specialized roles in innate immune cellular crosstalk. European Journal of Immunology, 46. p. 144. ISSN 0014-2980

Denton, A., Magiera, L., Watts, A., Fearon, D. (August 2016) Lymph node stromal cells derive from a distinct embryonic FAP plus progenitor. European Journal of Immunology, 46 (Supple). p. 507. ISSN 0014-2980

Fearon, D. (June 2016) Combination immunotherapy for cancer. J Exp Med, 213 (7). p. 1115. ISSN 1540-9538 (Electronic)0022-1007 (Linking)

Campos, J, Nayar, S, Croft, AP, Denton, AE, Fearon, DT, Buckley, CD, Barone, F (June 2016) DEPLETION OF LYMPHOID-LIKE STROMAL CELLS IMPAIRS TERTIARY LYMPHOID ORGAN FORMATION IN AN ANIMAL MODEL OF SJOGREN'S SYNDROME. In: Annual European Congress of Rheumatology.

Mellman, I., Hubbard-Lucey, V. M., Tontonoz, M. J., Kalos, M. D., Chen, D. S., Allison, J. P., Drake, C. G., Levitsky, H., Lonberg, N., van der Burg, S. H., Fearon, D. T., Wherry, E. J., Lowy, I., Vonderheide, R. H., Hwu, P. (April 2016) De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute. Cancer Immunol Res, 4 (4). pp. 279-88. ISSN 2326-6074 (Electronic)2326-6066 (Linking)

Joyce, J. A., Fearon, D. T. (April 2015) T cell exclusion, immune privilege, and the tumor microenvironment. Science, 348 (6230). pp. 74-80. ISSN 0036-8075

Dos Santos, L. I., Galvao-Filho, B., de Faria, P. C., Junqueira, C., Dutra, M. S., Teixeira, S. M., Rodrigues, M. M., Ritter, G., Bannard, O., Fearon, D. T., Antonelli, L. R., Gazzinelli, R. T. (March 2015) Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1. Cancer Immunol Immunother, 64 (3). pp. 311-23. ISSN 0340-7004

Crompton, J. G., Sukumar, M., Roychoudhuri, R., Clever, D., Gros, A., Eil, R. L., Tran, E., Hanada, K., Yu, Z., Palmer, D. C., Kerkar, S. P., Michalek, R. D., Upham, T., Leonardi, A., Acquavella, N., Wang, E., Marincola, F. M., Gattinoni, L., Muranski, P., Sundrud, M. S., Klebanoff, C. A., Rosenberg, S. A., Fearon, D. T., Restifo, N. P. (January 2015) Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics. Cancer Res, 75 (2). pp. 296-305. ISSN 0008-5472

Galluzzi, L., Vacchelli, E., Bravo-San Pedro, J., Buque, A., Senovilla, L., Baracco, E. E., Bloy, N., Castoldi, F., Abastado, J., Agostinis, P., Apte, R. N., Aranda, F., Ayyoub, M., Beckhove, P., Blay, J., Bracci, L., Caignard, A., Castelli, C., Cavallo, F., Celis, E., Cerundolo, V., Clayton, A., Colombo, M. P., Coussens, L., Dhodapkar, M. V., Eggermont, A. M., Fearon, D. T., Fridman, W. H., Fucikova, J., Gabrilovich, D. I., Galon, J., Garg, A., Ghiringhelli, F., Giaccone, G., Gilboa, E., Gnjatic, S., Hoos, A., Hosmalin, A., Jager, D., Kalinski, P., Karre, K., Kepp, O., Kiessling, R., Kirkwood, J. M., Klein, E., Knuth, A., Lewis, C. E., Liblau, R., Lotze, M. T., Lugli, E., Mach, J., Mattei, F., Mavilio, D., Melero, I., Melief, C. J., Mittendorf, E. A., Moretta, L., Odunsi, A., Okada, H., Palucka, A. K., Peter, M. E., Pienta, K. J., Porgador, A., Prendergast, G. C., Rabinovich, G. A., Restifo, N. P., Rizvi, N., Sautes-Fridman, C., Schreiber, H., Seliger, B., Shiku, H., Silva-Santos, B., Smyth, M. J., Speiser, D. E., Spisek, R., Srivastava, P. K., Talmadge, J. E., Tartour, E., Van Der Burg, S. H., Van Den Eynde, B. J., Vile, R., Wagner, H., Weber, J. S., Whiteside, T. L., Wolchok, J. D., Zitvogel, L., Zou, W., Kroemer, G. (December 2014) Classification of current anticancer immunotherapies. Oncotarget, 5 (24). ISSN 1949-2553

Feig, C., Jones, J. O., Kraman, M., Wells, R. J. B., Deonarine, A., Chan, D. S., Connell, C. M., Roberts, E. W., Zhao, Q., Caballero, O. L., Teichmann, S. A., Janowitz, T., Jodrell, D. I., Tuveson, D. A., Fearon, D. T. (December 2013) Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 110 (50). pp. 20212-20217. ISSN 00278424 (ISSN)

Roberts, E. W., Deonarine, A., Jones, J. O., Denton, A. E., Feig, C., Lyons, S. K., Espeli, M., Kraman, M., McKenna, B., Wells, R. J. B., Zhao, Q., Caballero, O. L., Larder, R., Coll, A. P., O'Rahilly, S., Brindle, K. M., Teichmann, S. A., Tuveson, D. A., Fearon, D. T. (June 2013) Depletion of stromal cells expressing fibroblast activation protein-alpha from skeletal muscle and bone marrow results in cachexia and anemia. Journal of Experimental Medicine, 210 (6). pp. 1137-1151. ISSN 0022-1007

Thaventhiran, J. E., Hoffmann, A., Magiera, L., de la Roche, M., Lingel, H., Brunner-Weinzierl, M., Fearon, D. T. (August 2012) Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell. Proc Natl Acad Sci U S A, 109 (33). E2223-9. ISSN 1091-6490 (Electronic)0027-8424 (Linking)

Mackay, L. K., Wakim, L., van Vliet, C. J., Jones, C. M., Mueller, S. N., Bannard, O., Fearon, D. T., Heath, W. R., Carbone, F. R. (March 2012) Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection. J Immunol, 188 (5). pp. 2173-8. ISSN 0022-1767

Kraman, M., Bambrough, P. J., Arnold, J. N., Roberts, E. W., Magiera, L., Jones, J. O., Gopinathan, A., Tuveson, D. A., Fearon, D. T. (November 2010) Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. Science, 330 (6005). pp. 827-30. ISSN 1095-9203 (Electronic)0036-8075 (Linking)

Bannard, O., Kraman, M., Fearon, D. T. (January 2009) Secondary replicative function of CD8+ T cells that had developed an effector phenotype. Science, 323 (5913). pp. 505-9. ISSN 1095-9203 (Electronic)0036-8075 (Linking)