Metabolism in acute myeloid leukemia: mechanistic insights and therapeutic targets

Mishra, Sushanta Kumar, Millman, Scott Evan, Zhang, Lingbo (December 2022) Metabolism in acute myeloid leukemia: mechanistic insights and therapeutic targets. Blood. ISSN 0006-4971

DOI: 10.1182/blood.2022018092


Metabolic rewiring and cellular reprogramming are trademarks of neoplastic initiation and progression in acute myeloid leukemia (AML). Metabolic alteration in leukemia cells is often genotype-specific, with associated changes in epigenetic and functional factors resulting in the downstream upregulation or facilitation of oncogenic pathways. Targeting abnormal or disease-sustaining metabolic activities in AML provides a wide range of therapeutic opportunities, ideally with enhanced therapeutic windows and robust clinical efficacy. This review highlights the dysregulation of amino acid, nucleotide, lipid, and carbohydrate metabolism in AML, explores the role of key vitamins and enzymes that regulate these processes, and provides an overview of metabolism-directed therapies currently in use or development.

Item Type: Paper
Subjects: diseases & disorders > cancer
diseases & disorders > cancer > cancer types > acute myeloid leukemia
therapies > cancer drugs - see diseases-cancer-drugs and therapies
CSHL Authors:
Communities: CSHL labs > Zhang L. lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 22 December 2022
Date Deposited: 31 Mar 2023 20:07
Last Modified: 31 Mar 2023 20:07

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving