Mishra, Sushanta Kumar, Millman, Scott Evan, Zhang, Lingbo (December 2022) Metabolism in acute myeloid leukemia: mechanistic insights and therapeutic targets. Blood. ISSN 0006-4971
Abstract
Metabolic rewiring and cellular reprogramming are trademarks of neoplastic initiation and progression in acute myeloid leukemia (AML). Metabolic alteration in leukemia cells is often genotype-specific, with associated changes in epigenetic and functional factors resulting in the downstream upregulation or facilitation of oncogenic pathways. Targeting abnormal or disease-sustaining metabolic activities in AML provides a wide range of therapeutic opportunities, ideally with enhanced therapeutic windows and robust clinical efficacy. This review highlights the dysregulation of amino acid, nucleotide, lipid, and carbohydrate metabolism in AML, explores the role of key vitamins and enzymes that regulate these processes, and provides an overview of metabolism-directed therapies currently in use or development.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer diseases & disorders therapies diseases & disorders > cancer > cancer types > acute myeloid leukemia therapies > cancer drugs - see diseases-cancer-drugs and therapies organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell transformation organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions diseases & disorders > cancer > cancer types |
| CSHL Authors: | |
| Communities: | CSHL labs > Zhang L. lab CSHL Cancer Center Program CSHL Cancer Center Program > Gene Regulation and Inheritance Program |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 22 December 2022 |
| Date Deposited: | 31 Mar 2023 20:07 |
| Last Modified: | 09 Feb 2024 15:32 |
| PMCID: | PMC10375271 |
| URI: | https://repository.cshl.edu/id/eprint/40777 |
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