ΔNp63α in cancer: importance and therapeutic opportunities

Fisher, Matthew L, Balinth, Seamus, Mills, Alea A (September 2022) ΔNp63α in cancer: importance and therapeutic opportunities. Trends in Cell Biology. S0962-8924(22)00194. ISSN 0962-8924

URL: https://www.ncbi.nlm.nih.gov/pubmed/36115734
DOI: 10.1016/j.tcb.2022.08.003

Abstract

Our understanding of cancer and the key pathways that drive cancer survival has expanded rapidly over the past several decades. However, there are still important challenges that continue to impair patient survival, including our inability to target cancer stem cells (CSCs), metastasis, and drug resistance. The transcription factor p63 is a p53 family member with multiple isoforms that carry out a wide array of functions. Here, we discuss the critical importance of the ΔNp63α isoform in cancer and potential therapeutic strategies to target ΔNp63α expression to impair the CSC population, as well as to prevent metastasis and drug resistance to improve patient survival.

Item Type: Paper
Subjects: diseases & disorders > cancer
CSHL Authors:
Communities: CSHL labs > Mills lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 14 September 2022
Date Deposited: 20 Sep 2022 21:23
Last Modified: 20 Sep 2022 21:23
URI: https://repository.cshl.edu/id/eprint/40720

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