A fragment based click chemistry approach towards hybrid G-quadruplex ligands: design, synthesis and biophysical evaluation

Ritson, Dougal J, Moses, John E (January 2012) A fragment based click chemistry approach towards hybrid G-quadruplex ligands: design, synthesis and biophysical evaluation. Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr, 68 (1). pp. 197-203. ISSN 0040-4020

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DOI: 10.1016/j.tet.2011.10.066

Abstract

A library of hybrid oxazole-triazole based compounds containing contiguously linked aromatic units were synthesised as G-quadruplex binding ligands. The design of these ligands was based upon combining features of our first generation of G-quadruplex bis-triazole ligands and the natural product telomestatin. The syntheses and biophysical studies of these ligands are described. © 2011 Elsevier B.V. All rights reserved.

Item Type: Paper
Subjects: chemistry > chemical synthesis
chemistry > techniques > click chemistry
CSHL Authors:
Communities: CSHL labs > Moses lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 7 January 2012
Date Deposited: 09 Jul 2021 15:41
Last Modified: 09 Jul 2021 15:41
Related URLs:
URI: https://repository.cshl.edu/id/eprint/40267

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