A fragment based click chemistry approach towards hybrid G-quadruplex ligands: design, synthesis and biophysical evaluation

Ritson, Dougal J, Moses, John E (January 2012) A fragment based click chemistry approach towards hybrid G-quadruplex ligands: design, synthesis and biophysical evaluation. Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr, 68 (1). pp. 197-203. ISSN 0040-4020

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Abstract

A library of hybrid oxazole-triazole based compounds containing contiguously linked aromatic units were synthesised as G-quadruplex binding ligands. The design of these ligands was based upon combining features of our first generation of G-quadruplex bis-triazole ligands and the natural product telomestatin. The syntheses and biophysical studies of these ligands are described. © 2011 Elsevier B.V. All rights reserved.

Item Type:	Paper
Subjects:	chemistry > chemical synthesis chemistry > techniques > click chemistry
CSHL Authors:	Moses, John E.
Communities:	CSHL labs > Moses lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	7 January 2012
Date Deposited:	09 Jul 2021 15:41
Last Modified:	09 Jul 2021 15:41
Related URLs:	Author
URI:	https://repository.cshl.edu/id/eprint/40267

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