Enhancing the Efficacy of Glutamine Metabolism Inhibitors in Cancer Therapy

Yang, Wen-Hsuan, Qiu, Yijian, Stamatatos, Olivia, Janowitz, Tobias, Lukey, Michael J (May 2021) Enhancing the Efficacy of Glutamine Metabolism Inhibitors in Cancer Therapy. Trends in Cancer. ISSN 2405-8033

Abstract

Glutamine metabolism is reprogrammed during tumorigenesis and has been investigated as a promising target for cancer therapy. However, efforts to drug this process are confounded by the intrinsic metabolic heterogeneity and flexibility of tumors, as well as the risk of adverse effects on the anticancer immune response. Recent research has yielded important insights into the mechanisms that determine the tumor and the host immune responses to pharmacological perturbation of glutamine metabolism. Here, we discuss these findings and suggest that, collectively, they point toward patient stratification and drug combination strategies to maximize the efficacy of glutamine metabolism inhibitors as cancer therapeutics.

Item Type:	Paper
Subjects:	diseases & disorders diseases & disorders > neoplasms organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > organs types and functions > metabolism organs, tissues, organelles, cell types and functions diseases & disorders > pulmonary disease > oxidative stress diseases & disorders > pulmonary disease diseases & disorders > cancer > drugs and therapies > tumor microenvironment
CSHL Authors:	Janowitz, Tobias Lukey, Michael Yang, Wen-Hsuan Qiu, Yijian Stamatatos, Olivia
Communities:	CSHL Cancer Center Program CSHL labs > Janowitz lab CSHL labs > Lukey lab CSHL Cancer Center Program > Cancer Genetics and Genomics Program
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	18 May 2021
Date Deposited:	26 May 2021 14:39
Last Modified:	24 Feb 2025 20:45
PMCID:	PMC9064286
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/40167

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