Top-down coordination of local cortical state during selective attention

van Kempen, J., Gieselmann, M. A., Boyd, M., Steinmetz, N. A., Moore, T., Engel, T. A., Thiele, A. (December 2020) Top-down coordination of local cortical state during selective attention. Neuron. ISSN 0896-6273

DOI: 10.1016/j.neuron.2020.12.013


Spontaneous fluctuations in cortical excitability influence sensory processing and behavior. These fluctuations, long thought to reflect global changes in cortical state, were recently found to be modulated locally within a retinotopic map during spatially selective attention. We report that periods of vigorous (On) and faint (Off) spiking activity, the signature of cortical state fluctuations, are coordinated across brain areas with retinotopic precision. Top-down attention enhanced interareal local state coordination, traversing along the reverse cortical hierarchy. The extent of local state coordination between areas was predictive of behavioral performance. Our results show that cortical state dynamics are shared across brain regions, modulated by cognitive demands and relevant for behavior.

Item Type: Paper
Subjects: organism description > animal behavior > attention
neurobiology > neuroscience
organism description > animal behavior > vision
CSHL Authors:
Communities: CSHL labs > Engel lab
Depositing User: Matthew Dunn
Date: 30 December 2020
Date Deposited: 11 Jan 2021 17:30
Last Modified: 29 Jun 2021 17:52
PMCID: PMC7927916
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