van Kempen, J., Gieselmann, M. A., Boyd, M., Steinmetz, N. A., Moore, T., Engel, T. A., Thiele, A. (December 2020) Top-down coordination of local cortical state during selective attention. Neuron. ISSN 0896-6273
Abstract
Spontaneous fluctuations in cortical excitability influence sensory processing and behavior. These fluctuations, long thought to reflect global changes in cortical state, were recently found to be modulated locally within a retinotopic map during spatially selective attention. We report that periods of vigorous (On) and faint (Off) spiking activity, the signature of cortical state fluctuations, are coordinated across brain areas with retinotopic precision. Top-down attention enhanced interareal local state coordination, traversing along the reverse cortical hierarchy. The extent of local state coordination between areas was predictive of behavioral performance. Our results show that cortical state dynamics are shared across brain regions, modulated by cognitive demands and relevant for behavior.
| Item Type: | Paper |
|---|---|
| Subjects: | organism description > animal organism description > animal behavior organism description > animal behavior > attention organism description > animal > mammal organism description > animal > mammal > primates > monkey neurobiology neurobiology > neuroscience organs, tissues, organelles, cell types and functions organism description > animal > mammal > primates organs, tissues, organelles, cell types and functions > tissues types and functions organism description > animal behavior > vision organism description > animal behavior > visual organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex organism description > animal behavior > visual discrimination |
| CSHL Authors: | |
| Communities: | CSHL labs > Engel lab |
| Depositing User: | Matthew Dunn |
| Date: | 30 December 2020 |
| Date Deposited: | 11 Jan 2021 17:30 |
| Last Modified: | 01 Feb 2024 19:12 |
| PMCID: | PMC7927916 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/39885 |
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