An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne

Spiteri, C., Mason, C., Zhang, F., Ritson, D. J., Sharma, P., Keeling, S., Moses, J. E. (June 2010) An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne. Org Biomol Chem, 8 (11). pp. 2537-42. ISSN 1477-0520

Abstract

An efficient protocol for the synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reactants simultaneously.

Item Type: Paper
Additional Information: 1477-0539 Spiteri, Christian Mason, Christopher Zhang, Fengzhi Ritson, Dougal J Sharma, Pallavi Keeling, Steve Moses, John E Journal Article Research Support, Non-U.S. Gov't England Org Biomol Chem. 2010 Jun 7;8(11):2537-42. doi: 10.1039/b927235f. Epub 2010 Apr 7.
Uncontrolled Keywords: Benzene Derivatives/*chemistry Cyclization Isoxazoles/*chemical synthesis/chemistry Molecular Structure Nitriles/*chemistry Oxides/*chemistry ortho-Aminobenzoates/chemistry
CSHL Authors:
Communities: CSHL labs > Moses lab
Depositing User: Matthew Dunn
Date: 7 June 2010
Date Deposited: 19 Apr 2021 20:28
Last Modified: 19 Apr 2021 20:28
Related URLs:
URI: https://repository.cshl.edu/id/eprint/39545

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