Starving the Devourer: Cutting Cancer Off from Its Favorite Foods

Katt, W. P., Lukey, M. J., Cerione, R. A. (September 2019) Starving the Devourer: Cutting Cancer Off from Its Favorite Foods. Cell Chem Biol, 26 (9). pp. 1197-1199. ISSN 2451-9448

URL: https://www.ncbi.nlm.nih.gov/pubmed/31539503
DOI: 10.1016/j.chembiol.2019.09.005

Abstract

Increased consumption of glucose and glutamine are metabolic hallmarks of tumorigenesis. In this issue of Cell Chemical Biology, Reckzeh et al. (2019) describe the discovery of Glutor, a potent inhibitor of cellular glucose uptake. Combining Glutor with the glutaminase inhibitor CB-839 creates a metabolic crisis in cancer cells, synergistically impeding proliferation.

Item Type: Paper
Subjects: diseases & disorders > cancer
diseases & disorders > cancer > drugs and therapies
organs, tissues, organelles, cell types and functions > organs types and functions > metabolism
CSHL Authors:
Communities: CSHL labs > Lukey lab
Depositing User: Adrian Gomez
Date: 19 September 2019
Date Deposited: 27 Jan 2020 16:08
Last Modified: 27 Jan 2020 16:08
Related URLs:
URI: https://repository.cshl.edu/id/eprint/38933

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