Stressing Out about Cancer Immunotherapy

He, X. Y., Ng, D., Van Aelst, L., Egeblad, M. (November 2019) Stressing Out about Cancer Immunotherapy. Cancer Cell, 36 (5). pp. 468-470. ISSN 15356108 (ISSN)

URL: https://www.ncbi.nlm.nih.gov/pubmed/31715130
DOI: 10.1016/j.ccell.2019.10.013

Abstract

Stress has long been suspected to negatively influence cancer mortality, yet the molecular mechanisms responsible for this effect have only recently been identified. A new study identifies a stress-induced response in dendritic cells—the activation of the glucocorticoid-inducible transcriptional regulator TSC22D3—as a potent, immunosuppressive effect of stress on cancer. © 2019 Elsevier Inc. Stress has long been suspected to negatively influence cancer mortality, yet the molecular mechanisms responsible for this effect have only recently been identified. A new study identifies a stress-induced response in dendritic cells—the activation of the glucocorticoid-inducible transcriptional regulator TSC22D3—as a potent, immunosuppressive effect of stress on cancer. © 2019 Elsevier Inc.

Item Type: Paper
Additional Information: Cancer Cell
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > hormones
diseases & disorders > physiological stress
CSHL Authors:
Communities: CSHL Cancer Center Program
CSHL labs > Egeblad lab
CSHL labs > Van Aelst lab
Depositing User: Adrian Gomez
Date: 11 November 2019
Date Deposited: 20 Nov 2019 20:44
Last Modified: 20 Nov 2019 20:44
Related URLs:
URI: https://repository.cshl.edu/id/eprint/38714

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