Stressing Out about Cancer Immunotherapy

He, X. Y., Ng, D., Van Aelst, L., Egeblad, M. (November 2019) Stressing Out about Cancer Immunotherapy. Cancer Cell, 36 (5). pp. 468-470. ISSN 15356108 (ISSN)

URL: https://www.ncbi.nlm.nih.gov/pubmed/31715130

DOI: 10.1016/j.ccell.2019.10.013

Abstract

Stress has long been suspected to negatively influence cancer mortality, yet the molecular mechanisms responsible for this effect have only recently been identified. A new study identifies a stress-induced response in dendritic cells—the activation of the glucocorticoid-inducible transcriptional regulator TSC22D3—as a potent, immunosuppressive effect of stress on cancer. © 2019 Elsevier Inc. Stress has long been suspected to negatively influence cancer mortality, yet the molecular mechanisms responsible for this effect have only recently been identified. A new study identifies a stress-induced response in dendritic cells—the activation of the glucocorticoid-inducible transcriptional regulator TSC22D3—as a potent, immunosuppressive effect of stress on cancer. © 2019 Elsevier Inc.

Item Type:	Paper
Additional Information:	Cancer Cell
Subjects:	bioinformatics diseases & disorders > cancer diseases & disorders bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics diseases & disorders > neoplasms bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells diseases & disorders > cancer > drugs and therapies bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > hormones diseases & disorders > cancer > drugs and therapies > Immunotherapy organs, tissues, organelles, cell types and functions diseases & disorders > physiological stress bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:	Egeblad, Mikala Van Aelst, Linda He, Xueyan Ng, David
Communities:	CSHL Cancer Center Program CSHL labs > Egeblad lab CSHL labs > Van Aelst lab
Depositing User:	Adrian Gomez
Date:	11 November 2019
Date Deposited:	20 Nov 2019 20:44
Last Modified:	02 Feb 2024 15:36
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/38714

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