Boj, S. F., Hwang, C. I., Baker, L. A., Engle, D. D., Tuveson, D. A., Clevers, H. (January 2016) Model organoids provide new research opportunities for ductal pancreatic cancer. Mol Cell Oncol, 3 (1). e1014757. ISSN 2372-3556 (Electronic)2372-3556 (Linking)
Abstract
We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | cancer organoids pancreatic ductal adenocarcinoma preclinical models |
| Subjects: | Investigative techniques and equipment > cell culture organism description > model organism diseases & disorders > cancer > cancer types > pancreatic cancer |
| CSHL Authors: | |
| Communities: | CSHL labs > Tuveson lab |
| Depositing User: | Matt Covey |
| Date: | January 2016 |
| Date Deposited: | 23 Jun 2016 16:18 |
| Last Modified: | 23 Jun 2016 16:18 |
| PMCID: | PMC4845167 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/32873 |
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