Model organoids provide new research opportunities for ductal pancreatic cancer

Boj, S. F., Hwang, C. I., Baker, L. A., Engle, D. D., Tuveson, D. A., Clevers, H. (January 2016) Model organoids provide new research opportunities for ductal pancreatic cancer. Mol Cell Oncol, 3 (1). e1014757. ISSN 2372-3556 (Electronic)2372-3556 (Linking)

DOI: 10.1080/23723556.2015.1014757


We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.

Item Type: Paper
Uncontrolled Keywords: cancer organoids pancreatic ductal adenocarcinoma preclinical models
Subjects: Investigative techniques and equipment > cell culture
organism description > model organism
diseases & disorders > cancer > cancer types > pancreatic cancer
CSHL Authors:
Communities: CSHL labs > Tuveson lab
Depositing User: Matt Covey
Date: January 2016
Date Deposited: 23 Jun 2016 16:18
Last Modified: 23 Jun 2016 16:18
PMCID: PMC4845167
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