ROS in translation: Chink in the armor

Chio, II, Tuveson, D. A. (2017) ROS in translation: Chink in the armor. Cell Cycle, 16 (4). pp. 297-298. ISSN 1551-4005

URL: https://www.ncbi.nlm.nih.gov/pubmed/27636545
DOI: 10.1080/15384101.2016.1232087

Abstract

Pancreatic ductal adenocarcinoma (PDA) holds the most dismal prognosis among the common malignancies and is considered to be largely incurable. In spite of extensive efforts in preclinical and clinical science, the survival rate of pancreatic cancer has not improved substantially over the past 40 y. An activating mutation of KRAS is the most common genetic perturbation found in PDA, occurring in 90-95% of the cases. Despite the identification of a clear driver oncogene, clinically actionable strategies to target KRAS have not yet been identified. A deeper understanding of the molecular events downstream of KRAS is therefore critical for the development of new therapeutic interventions for this deadly disease.

Item Type: Paper
Uncontrolled Keywords: Nrf2 cysteine thiols pancreatic cancer protein synthesis redox homeostasis
Subjects: diseases & disorders > cancer > cancer types > pancreatic cancer
CSHL Authors:
Communities: CSHL labs > Tuveson lab
CSHL Cancer Center Program > Signal Transduction
Depositing User: Matt Covey
Date Deposited: 16 Feb 2017 17:20
Last Modified: 13 Jun 2018 15:50
Related URLs:
URI: http://repository.cshl.edu/id/eprint/34128

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