From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

Hattangadi, S. M., Wong, P., Zhang, L., Flygare, J., Lodish, H. F. (2011) From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications. Blood, 118 (24). pp. 6258-68. ISSN 1528-0020 (Electronic)0006-4971 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/21998215
DOI: 10.1182/blood-2011-07-356006

Abstract

This article reviews the regulation of production of RBCs at several levels. We focus on the regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other factors that occur during chronic anemia, inflammation, and other conditions of stress. We also highlight the rapid production of RBCs by the coordinated regulation of terminal proliferation and differentiation of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as erythropoietin and adhesion to a fibronectin matrix. We discuss the complex intracellular networks of coordinated gene regulation by transcription factors, chromatin modifiers, and miRNAs that regulate the different stages of erythropoiesis.

Item Type: Paper
Uncontrolled Keywords: Animals Cell Proliferation Chromatin/metabolism Epigenesis, Genetic Erythrocytes/ cytology/metabolism Erythroid Precursor Cells/ cytology/metabolism Erythropoiesis Erythropoietin/metabolism Humans MicroRNAs/metabolism Models, Biological Transcription, Genetic
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA expression
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell differentiation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > Chromatin dynamics
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell differentiation > erythropoiesis
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells
CSHL Authors:
Communities: CSHL labs > Zhang L. lab
Depositing User: Matt Covey
Date Deposited: 13 Jul 2015 16:44
Last Modified: 13 Jul 2015 16:44
PMCID: PMC3236116
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31621

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving