Hattangadi, S. M., Wong, P., Zhang, L., Flygare, J., Lodish, H. F.
(December 2011)
From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications.
Blood, 118 (24).
pp. 6258-68.
ISSN 1528-0020 (Electronic)0006-4971 (Linking)
Abstract
This article reviews the regulation of production of RBCs at several levels. We focus on the regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other factors that occur during chronic anemia, inflammation, and other conditions of stress. We also highlight the rapid production of RBCs by the coordinated regulation of terminal proliferation and differentiation of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as erythropoietin and adhesion to a fibronectin matrix. We discuss the complex intracellular networks of coordinated gene regulation by transcription factors, chromatin modifiers, and miRNAs that regulate the different stages of erythropoiesis.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Animals
Cell Proliferation
Chromatin/metabolism
Epigenesis, Genetic
Erythrocytes/ cytology/metabolism
Erythroid Precursor Cells/ cytology/metabolism
Erythropoiesis
Erythropoietin/metabolism
Humans
MicroRNAs/metabolism
Models, Biological
Transcription, Genetic |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA expression
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell differentiation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > Chromatin dynamics
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell differentiation > erythropoiesis
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Zhang L. lab |
| Depositing User: |
Matt Covey
|
| Date: |
8 December 2011 |
| Date Deposited: |
13 Jul 2015 16:44 |
| Last Modified: |
13 Jul 2015 16:44 |
| PMCID: |
PMC3236116 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/31621 |
Actions (login required)
 |
Administrator's edit/view item |
