CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila

Yin, J. C., Del Vecchio, M., Zhou, H., Tully, T. (April 1995) CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell, 81 (1). pp. 107-15. ISSN 0092-8674 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/7720066
DOI: 10.1016/0092-8674(95)90375-5

Abstract

Genetic studies of memory formation in Drosophila have revealed that the formation of a protein synthesis-dependent long-term memory (LTM) requires multiple training sessions. LTM is blocked specifically by induced expression of a repressor isoform of the cAMP-responsive element-binding protein (CREB). Here, we report an enhancement of LTM formation after induced expression of an activator isoform of dCREB2. Maximum LTM is achieved after one training session, and its formation depends on phosphorylation of the activator transgene. A model of LTM formation based on differential regulation of CREB isoforms is proposed.

Item Type: Paper
Uncontrolled Keywords: Animals Animals, Genetically Modified Avoidance Learning Cyclic AMP Response Element-Binding Protein/ biosynthesis/genetics/metabolism/physiology Drosophila/genetics/ physiology Gene Expression Genes, Insect Heat Memory/ physiology Models, Genetic Mutation/physiology Phosphorylation Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Trans-Activators/ biosynthesis/genetics/metabolism/physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor > CREB
organism description > animal > insect > Drosophila
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
organism description > animal behavior > memory
CSHL Authors:
Communities: CSHL labs > Tully lab
CSHL labs > Yin lab
Depositing User: Jessica Koos
Date: 7 April 1995
Date Deposited: 31 Jul 2014 15:49
Last Modified: 31 Jul 2014 15:49
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30655

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