Yin, J. C., Del Vecchio, M., Zhou, H., Tully, T. (April 1995) CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell, 81 (1). pp. 107-15. ISSN 0092-8674 (Print)
Abstract
Genetic studies of memory formation in Drosophila have revealed that the formation of a protein synthesis-dependent long-term memory (LTM) requires multiple training sessions. LTM is blocked specifically by induced expression of a repressor isoform of the cAMP-responsive element-binding protein (CREB). Here, we report an enhancement of LTM formation after induced expression of an activator isoform of dCREB2. Maximum LTM is achieved after one training session, and its formation depends on phosphorylation of the activator transgene. A model of LTM formation based on differential regulation of CREB isoforms is proposed.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Animals, Genetically Modified Avoidance Learning Cyclic AMP Response Element-Binding Protein/ biosynthesis/genetics/metabolism/physiology Drosophila/genetics/ physiology Gene Expression Genes, Insect Heat Memory/ physiology Models, Genetic Mutation/physiology Phosphorylation Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Trans-Activators/ biosynthesis/genetics/metabolism/physiology |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor > CREB organism description > animal > insect > Drosophila bioinformatics > genomics and proteomics > genetics & nucleic acid processing organism description > animal behavior > memory |
| CSHL Authors: | |
| Communities: | CSHL labs > Tully lab CSHL labs > Yin lab |
| Depositing User: | Jessica Koos |
| Date: | 7 April 1995 |
| Date Deposited: | 31 Jul 2014 15:49 |
| Last Modified: | 31 Jul 2014 15:49 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30655 |
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