Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line

Shimizu, K., Goldfarb, M., Perucho, M., Wigler, M. H. (January 1983) Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc Natl Acad Sci U S A, 80 (2). pp. 383-387.

[img]
Preview
PDF (Paper)
Wigler PNAS 1983.pdf - Published Version

Download (1688Kb) | Preview
URL: https://www.ncbi.nlm.nih.gov/pubmed/6300838
DOI: 10.1073/pnas.80.2.383

Abstract

DNA from the human neuroblastoma cell line SK-N-SH is capable of inducing foci of transformed NIH 3T3 cells after DNA-mediated gene transfer. using genetic selection with the Escherichia coli sup F gene, we have isolated human sequences from mouse cells responsible for the oncogenic transformation. These sequences are present in all human DNAs surveyed and no gross rearrangements of these sequences are found in SK-N-SH cells. Although clearly distinct from two other human transforming genes present in bladder, lung, and colon carcinoma cell lines, all three transforming gene sequences may be related members of the ras gene family.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > RAS
bioinformatics > genomics and proteomics > annotation > sequence annotation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
CSHL Authors:
Communities: CSHL labs > Wigler lab
Depositing User: CSHL Librarian
Date: 15 January 1983
Date Deposited: 11 Apr 2012 20:30
Last Modified: 09 Nov 2017 20:51
PMCID: PMC393381
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26239

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving