Rapid and Precise Control of Sniffing during Olfactory Discrimination in Rats

Kepecs, A., Uchida, N., Mainen, Z. F. (July 2007) Rapid and Precise Control of Sniffing during Olfactory Discrimination in Rats. J Neurophysiol, 98 (1). pp. 205-213. ISSN 0022-3077 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/17460109
DOI: 10.1152/jn.00071.2007

Abstract

Olfactory perception relies on an active sampling process, sniffing, to rapidly deliver odorants from the environment to the olfactory receptors. The respiration cycle strongly patterns the flow of information into the olfactory systems, but the behavioral significance of particular sniffing patterns is not well understood. Here, we monitored the frequency and timing of nasal respiration in rats performing an odor mixture discrimination task that allowed us to test subjects near psychophysical limits and to quantify the precise timing of their behavior. We found that respiration frequencies varied widely from 2-12 Hz, but odor discrimination was dependent on 6-9 Hz sniffing: rats almost always entered and maintained this frequency band during odor sampling and their accuracy on difficult discrimination dropped when they did not. Moreover, the switch from baseline respiration to sniffing occurred not in response to odor delivery but in anticipation of odor sampling and was executed rapidly, almost always within a single cycle. Interestingly, rats also switched from respiration to rapid sniffing in anticipation of reward delivery, but in a distinct frequency band, 9-12 Hz. These results demonstrate the speed and precision of control over respiration and its significance for acquisition of olfactory information.

Item Type: Paper
Uncontrolled Keywords: RESPIRATORY RHYTHM GENERATION THETA-OSCILLATIONS AIR-FLOW BRAIN-STIMULATION BEHAVIOR WHISKING SYSTEM MODULATION HYPOTHESIS PLASTICITY
Subjects: organism description > animal behavior > olfactory
organism description > animal > mammal > rodent > rat
organism description > animal > mammal > rodent > rat

organism description > animal behavior > respiration
CSHL Authors:
Communities: CSHL labs > Kepecs lab
CSHL labs > Mainen lab
Depositing User: CSHL Librarian
Date: July 2007
Date Deposited: 11 Nov 2011 17:10
Last Modified: 03 Dec 2014 18:02
Related URLs:
URI: http://repository.cshl.edu/id/eprint/23062

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