Ancestral Roles of Small RNAs: An Ago-Centric Perspective

Joshua-Tor, L., Hannon, G. J. (2011) Ancestral Roles of Small RNAs: An Ago-Centric Perspective. Cold Spring Harb Perspect Biol, 3 (10). ISSN 1943-0264 (Electronic)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/20810548
DOI: 10.1101/cshperspect.a003772

Abstract

RNAi has existed at least since the divergence of prokaryotes and eukaryotes. This collection of pathways responds to a diversity of "abberant" RNAs and generally silences or eliminates genes sharing sequence content with the silencing trigger. In the canonical pathway, double-stranded RNAs are processed into small RNAs, which guide effector complexes to their targets by complementary base pairing. Many alternative routes from silencing trigger to small RNA are continuously being uncovered. Though the triggers of the pathway and the mechanisms of small RNA production are many, all RNAi-related mechanisms share Argonaute proteins as the heart of their effector complexes. These can act as self-contained silencing machines, binding directly to small RNAs, carrying out homology-based target recognition, and in some cases cleaving targets using an endogenous nuclease domain. Here, we discuss the diversity of Argonaute proteins from a structural and functional perspective.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
CSHL Authors:
Communities: CSHL labs > Hannon lab
CSHL labs > Joshua-Tor lab
Depositing User: CSHL Librarian
Date Deposited: 30 Sep 2011 20:43
Last Modified: 17 Dec 2014 15:33
PMCID: PMC3179341
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15443

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