Sun, Shoujun, Smith, Elliot J, Vishwakarma, Dharmendra, Moorhouse, Adam D, Moses, John E (September 2025) Introducing Germanium Click Chemistry: GeFEx-S - Thiol-Selective Fluoride Exchange On-Water. ChemRxiv. (Submitted)
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Abstract
We introduce germanium into the click chemistry family through the development of Germanium(IV) Fluoride Exchange-S (GeFEx-S), a thiol-selective reaction that enables rapid covalent bond formation under mild, “on-water” conditions. This transformation leverages the unique reactivity of tetravalent fluorogermanes to generate hydrolytically stable Ge–S linkages under biologically relevant conditions. GeFEx-S exhibits broad functional group tolerance - including compatibility with free cysteine residues - and operates orthogonally to established SuFEx and PFEx chemistries. By forming stable Ge–S bonds under aqueous conditions, GeFEx-S expands the fluoride exchange repertoire and establishes a versatile platform for site-selective bioconjugation, chemical probe development, and orthogonal functionalization in chemical biology and materials science.
| Item Type: | Paper |
|---|---|
| Subjects: | chemistry chemistry > techniques > click chemistry chemistry > techniques |
| CSHL Authors: | |
| Communities: | CSHL labs > Moses lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 11 September 2025 |
| Date Deposited: | 12 Sep 2025 13:23 |
| Last Modified: | 12 Sep 2025 13:23 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41960 |
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