Unlocking Cellular Memory and Gene Regulatory Networks: Pioneering the Future of Therapeutic Innovations

Momin, Md Sorique Aziz, Bhadra, Jhuma, Bhunia, Debmalya, Sannigrahi, Achinta, De, Nayan (June 2025) Unlocking Cellular Memory and Gene Regulatory Networks: Pioneering the Future of Therapeutic Innovations. Cells, 14 (12). p. 903. ISSN 2073-4409

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Abstract

Cellular memory is the competence of cells to preserve information from past experiences and respond aptly. This memory is maintained and controlled by gene regulatory networks (GRNs). GRNs are crucial for understanding why some cells are resistant to treatment, particularly for cancer. In our study, we created a new mathematical model to understand how "noise" affects cellular memory in GRNs, focusing on a "double positive feedback loop". Our theoretical perspective article equipped with mathematical modeling exhibits how noise and feedback loops interact in GRNs. It also proposes a potential theoretical avenue for future therapy. By targeting the mechanisms that maintain drug resistance in cells, we aim to develop therapies that can restore the sensitivity of cancer cells to treatment.

Item Type:	Paper
Subjects:	diseases & disorders diseases & disorders > neoplasms
CSHL Authors:	Bhunia, Debmalya
Communities:	CSHL labs > Wigler lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	14 June 2025
Date Deposited:	27 Jun 2025 17:35
Last Modified:	27 Jun 2025 17:35
PMCID:	PMC12191380
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41896

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