Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal

Hernandez, Diego E, Ciuparu, Andrei, Garcia da Silva, Pedro, Velasquez, Cristina M, Rebouillat, Benjamin, Gross, Michael D, Davis, Martin B, Chae, Honggoo, Muresan, Raul C, Albeanu, Dinu F (January 2025) Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal. Nature Communications, 16 (1). p. 937. ISSN 2041-1723 (Public Dataset)

[thumbnail of 10.1038.s41467-025-56023-5.pdf]

PDF
10.1038.s41467-025-56023-5.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.
Download (4MB)

URL: https://www.ncbi.nlm.nih.gov/pubmed/39843439

DOI: 10.1038/s41467-025-56023-5

Abstract

While animals readily adjust their behavior to adapt to relevant changes in the environment, the neural pathways enabling these changes remain largely unknown. Here, using multiphoton imaging, we investigate whether feedback from the piriform cortex to the olfactory bulb supports such behavioral flexibility. To this end, we engage head-fixed male mice in a multimodal rule-reversal task guided by olfactory and auditory cues. Both odor and, surprisingly, the sound cues trigger responses in the cortical bulbar feedback axons which precede the behavioral report. Responses to the same sensory cue are strongly modulated upon changes in stimulus-reward contingency (rule-reversals). The re-shaping of individual bouton responses occurs within seconds of the rule-reversal events and is correlated with changes in behavior. Optogenetic perturbation of cortical feedback within the bulb disrupts the behavioral performance. Our results indicate that the piriform-to-olfactory bulb feedback axons carry stimulus identity and reward contingency signals which are rapidly re-formatted according to changes in the behavioral context.

Item Type:	Paper
Subjects:	organism description > animal behavior organism description > animal behavior > olfactory organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Garcia Da Silva, Pedro Davis, Martin Albeanu, Dinu F. Hernandez Trejo, Diego Chae, Hong Goo
Communities:	CSHL labs > Albeanu lab CSHL labs > Banerjee lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	22 January 2025
Date Deposited:	23 Jan 2025 16:06
Last Modified:	23 Jan 2025 16:06
Related URLs:	Publisher
Dataset ID:	https://doi.org/10.6084/m9.figshare.26999638
URI:	https://repository.cshl.edu/id/eprint/41778

Actions (login required)

Administrator's edit/view item