Zubiete-Franco, Imanol, Tonks, Nicholas K (September 2024) Famotidine increases cellular phospho-tyrosine levels. Biochemical and Biophysical Research Communications, 734. p. 150763. ISSN 0006-291X
Abstract
While vaccines were being developed, the SARS-CoV-2 pandemic triggered a race to find known drugs that could be quickly repurposed to treat patients. One such candidate was famotidine, which retrospective cohort studies had shown increased survival in hospitalized patients. Computational studies had suggested that famotidine may target early viral proteases; however, ultimately, famotidine was shown not to function as a viral inhibitor. In contrast, we have observed a change in the cellular levels of phospho-tyrosine in A549 lung epithelial cells following treatment with famotidine. This quick change in phosphorylation was due mainly to a dose-dependent increase in cellular production of H2O2. Notably, these changes in phospho-tyrosine levels were able to affect cell signaling; we detected an increased short- and long-term response to IFNα stimulation. Our results suggest that famotidine can increase the anti-viral state of non-infected cells thereby potentially increasing viral resistance.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders therapies diseases & disorders > viral diseases diseases & disorders > viral diseases > coronavirus diseases & disorders > viral diseases > coronavirus > covid 19 therapies > famotidine |
| CSHL Authors: | |
| Communities: | CSHL Cancer Center Program > Cellular Communication in Cancer Program CSHL labs > Tonks lab CSHL Cancer Center Program |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 28 September 2024 |
| Date Deposited: | 07 Oct 2024 13:42 |
| Last Modified: | 20 Nov 2024 16:27 |
| PMCID: | PMC11490372 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41697 |
Actions (login required)
 |
Administrator's edit/view item |