Gustison, Morgan L, Muñoz-Castañeda, Rodrigo, Osten, Pavel, Phelps, Steven M (February 2024) Sexual coordination in a whole-brain map of prairie vole pair bonding. eLife, 12. RP87029. ISSN 2050-084X (Public Dataset)
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Abstract
Sexual bonds are central to the social lives of many species, including humans, and monogamous prairie voles have become the predominant model for investigating such attachments. We developed an automated whole-brain mapping pipeline to identify brain circuits underlying pair-bonding behavior. We identified bonding-related c-Fos induction in 68 brain regions clustered in seven major brain-wide neuronal circuits. These circuits include known regulators of bonding, such as the bed nucleus of the stria terminalis, paraventricular hypothalamus, ventral pallidum, and prefrontal cortex. They also include brain regions previously unknown to shape bonding, such as ventromedial hypothalamus, medial preoptic area, and the medial amygdala, but that play essential roles in bonding-relevant processes, such as sexual behavior, social reward, and territorial aggression. Contrary to some hypotheses, we found that circuits active during mating and bonding were largely sexually monomorphic. Moreover, c-Fos induction across regions was strikingly consistent between members of a pair, with activity best predicted by rates of ejaculation. A novel cluster of regions centered in the amygdala remained coordinated after bonds had formed, suggesting novel substrates for bond maintenance. Our tools and results provide an unprecedented resource for elucidating the networks that translate sexual experience into an enduring bond.
| Item Type: | Paper |
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| Subjects: | organism description > animal organism description > animal behavior |
| CSHL Authors: | |
| Communities: | CSHL labs > Mitra lab CSHL labs > Osten lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 21 February 2024 |
| Date Deposited: | 03 Oct 2024 18:02 |
| Last Modified: | 03 Oct 2024 18:02 |
| PMCID: | PMC10942618 |
| Related URLs: | |
| Dataset ID: |
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| URI: | https://repository.cshl.edu/id/eprint/41691 |
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