Banerjee, Arkarup, Isko, Emily, Harpole, Clifford, Zheng, Xiaoyue, Zhan, Huiqing, Davis, Martin, Zador, Anthony (September 2024) Selective expansion of motor cortical projections in the evolution of vocal novelty. bioRxiv. ISSN 2692-8205 (Submitted)
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10.1101.2024.09.13.612752v1.pdf - Submitted Version Available under License Creative Commons Attribution No Derivatives. Download (21MB) | Preview |
Abstract
Deciphering how cortical architecture evolves to drive behavioral innovations is a long-standing challenge in neuroscience and evolutionary biology. Here, we leverage a striking behavioral novelty in the Alston's singing mouse (Scotinomys teguina), compared to the laboratory mouse (Mus musculus), to quantitatively test models of motor cortical evolution. We used bulk tracing, serial two-photon tomography, and high-throughput DNA sequencing of over 76,000 barcoded neurons to discover a specific and substantial expansion (~200%) of orofacial motor cortical (OMC) projections to the auditory cortical region (AudR) and the midbrain periaqueductal gray (PAG), both implicated in vocal behaviors. Moreover, analysis of individual OMC neurons' projection motifs revealed preferential expansion of exclusive projections to AudR. Our results imply that selective expansion of ancestral motor cortical projections can underlie behavioral divergence over short evolutionary timescales, suggesting potential mechanisms for the evolution of enhanced cortical control over vocalizations, a crucial preadaptation for human language.
| Item Type: | Paper |
|---|---|
| Subjects: | organism description > animal organism description > animal > mammal organism description > animal > mammal > rodent > mouse neurobiology neurobiology > neuroscience organism description > animal > mammal > rodent |
| CSHL Authors: | |
| Communities: | CSHL labs > Zador lab CSHL labs > Banerjee lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 14 September 2024 |
| Date Deposited: | 16 Sep 2024 18:43 |
| Last Modified: | 16 Sep 2024 18:43 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41670 |
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