Uncovering 2-D toroidal representations in grid cell ensemble activity during 1-D behavior

Hermansen, Erik, Klindt, David A, Dunn, Benjamin A (June 2024) Uncovering 2-D toroidal representations in grid cell ensemble activity during 1-D behavior. Nature Communications, 15 (1). p. 5429. ISSN 2041-1723

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Abstract

Minimal experiments, such as head-fixed wheel-running and sleep, offer experimental advantages but restrict the amount of observable behavior, making it difficult to classify functional cell types. Arguably, the grid cell, and its striking periodicity, would not have been discovered without the perspective provided by free behavior in an open environment. Here, we show that by shifting the focus from single neurons to populations, we change the minimal experimental complexity required. We identify grid cell modules and show that the activity covers a similar, stable toroidal state space during wheel running as in open field foraging. Trajectories on grid cell tori correspond to single trial runs in virtual reality and path integration in the dark, and the alignment of the representation rapidly shifts with changes in experimental conditions. Thus, we provide a methodology to discover and study complex internal representations in even the simplest of experiments.

Item Type:	Paper
Subjects:	organism description > animal organism description > animal behavior organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organism description > animal > mammal organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions organism description > animal > mammal > rodent
CSHL Authors:	Klindt, David
Communities:	CSHL labs > Klindt lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	26 June 2024
Date Deposited:	01 Jul 2024 13:32
Last Modified:	01 Jul 2024 13:32
PMCID:	PMC11208534
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41589

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