Mapping model units to visual neurons reveals population code for social behaviour

Cowley, Benjamin R, Calhoun, Adam J, Rangarajan, Nivedita, Ireland, Elise, Turner, Maxwell H, Pillow, Jonathan W, Murthy, Mala (May 2024) Mapping model units to visual neurons reveals population code for social behaviour. Nature. ISSN 0028-0836 (Public Dataset)

PDF 10.1038.s41586-024-07451-8.pdf - Published Version Available under License Creative Commons Attribution. Download (19MB)

Abstract

The rich variety of behaviours observed in animals arises through the interplay between sensory processing and motor control. To understand these sensorimotor transformations, it is useful to build models that predict not only neural responses to sensory input1-5 but also how each neuron causally contributes to behaviour6,7. Here we demonstrate a novel modelling approach to identify a one-to-one mapping between internal units in a deep neural network and real neurons by predicting the behavioural changes that arise from systematic perturbations of more than a dozen neuronal cell types. A key ingredient that we introduce is 'knockout training', which involves perturbing the network during training to match the perturbations of the real neurons during behavioural experiments. We apply this approach to model the sensorimotor transformations of Drosophila melanogaster males during a complex, visually guided social behaviour8-11. The visual projection neurons at the interface between the optic lobe and central brain form a set of discrete channels12, and prior work indicates that each channel encodes a specific visual feature to drive a particular behaviour13,14. Our model reaches a different conclusion: combinations of visual projection neurons, including those involved in non-social behaviours, drive male interactions with the female, forming a rich population code for behaviour. Overall, our framework consolidates behavioural effects elicited from various neural perturbations into a single, unified model, providing a map from stimulus to neuronal cell type to behaviour, and enabling future incorporation of wiring diagrams of the brain15 into the model.

Item Type:	Paper
Subjects:	organism description > animal behavior organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions organism description > animal behavior > social
CSHL Authors:	Cowley, Benjamin
Communities:	CSHL labs > Cowley lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	22 May 2024
Date Deposited:	23 May 2024 12:31
Last Modified:	23 May 2024 12:31
Related URLs:	Publisher
Dataset ID:	https://dandiarchive.org/dandiset/000951/
URI:	https://repository.cshl.edu/id/eprint/41562

Actions (login required)

Administrator's edit/view item