Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression

Lam, Siew Hong, Wu, Yi Lian, Vega, Vinsensius B, Miller, Lance D, Spitsbergen, Jan, Tong, Yan, Zhan, Huiqing, Govindarajan, Kunde R, Lee, Serene, Mathavan, Sinnakarupan, Murthy, Karuturi R Krishna, Buhler, Donald R, Liu, Edison T, Gong, Zhiyuan (January 2006) Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression. Nature Biotechnology, 24 (1). pp. 73-75. ISSN 1087-0156

Abstract

The zebrafish (Danio rerio) has been long advocated as a model for cancer research, but little is known about the real molecular similarities between zebrafish and human tumors. Comparative analysis of microarray data from zebrafish liver tumors with those from four human tumor types revealed molecular conservation at various levels between fish and human tumors. This approach provides a useful strategy for identifying an expression signature that is strongly associated with a disease phenotype.

Item Type:	Paper
Subjects:	bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification diseases & disorders bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics diseases & disorders > neoplasms organism description > animal organism description > animal > fish bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function organism description > animal > fish > zebrafish
CSHL Authors:	Zhan, Huiqing
Communities:	CSHL labs > Zador lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	January 2006
Date Deposited:	22 Jan 2024 20:43
Last Modified:	22 Jan 2024 20:43
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41407

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