Lam, Siew Hong, Wu, Yi Lian, Vega, Vinsensius B, Miller, Lance D, Spitsbergen, Jan, Tong, Yan, Zhan, Huiqing, Govindarajan, Kunde R, Lee, Serene, Mathavan, Sinnakarupan, Murthy, Karuturi R Krishna, Buhler, Donald R, Liu, Edison T, Gong, Zhiyuan
(January 2006)
Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression.
Nature Biotechnology, 24 (1).
pp. 73-75.
ISSN 1087-0156
Abstract
The zebrafish (Danio rerio) has been long advocated as a model for cancer research, but little is known about the real molecular similarities between zebrafish and human tumors. Comparative analysis of microarray data from zebrafish liver tumors with those from four human tumor types revealed molecular conservation at various levels between fish and human tumors. This approach provides a useful strategy for identifying an expression signature that is strongly associated with a disease phenotype.
| Item Type: |
Paper
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| Subjects: |
bioinformatics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
diseases & disorders
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
diseases & disorders > neoplasms
organism description > animal
organism description > animal > fish
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
organism description > animal > fish > zebrafish |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Zador lab |
| SWORD Depositor: |
CSHL Elements
|
| Depositing User: |
CSHL Elements
|
| Date: |
January 2006 |
| Date Deposited: |
22 Jan 2024 20:43 |
| Last Modified: |
22 Jan 2024 20:43 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/41407 |
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