Sulfur Fluoride Exchange (SuFEx)

Giel, MC, Smedley, CJ, Moses, JE (January 2021) Sulfur Fluoride Exchange (SuFEx). In: Science of Synthesis. UNSPECIFIED, pp. 435-484.

DOI: 10.1055/sos-SD-235-00230


Sulfur Fluoride Exchange (SuFEx) click chemistry is a new generation technology for creating stable molecular connections with absolute reliability under metal-free conditions. SuFEx builds upon the fundamental principles of click chemistry by exploiting a unique blend of stability and latent reactivity of high oxidation state sulfur fluoride [e.g., S(VI)] functionalities to forge stable covalent linkages at connective SuFEx hubs. In this review, we focus mainly on the SuFEx hubs, sulfuryl fluoride (SO2F2), thionyl tetrafluoride (SOF4), ethenesulfonyl fluoride (ESF), 1-bromoethene-1-sulfonyl fluoride (BESF) and, 2-substituted alkyne-1-sulfonyl fluorides (SASFs). We describe each connector's unique reactivity and their application to SuFEx click chemistry.

Item Type: Book Section
Subjects: chemistry > techniques > click chemistry > Accelerated SuFEx Click Chemistry
chemistry > techniques > click chemistry
CSHL Authors:
Communities: CSHL labs > Moses lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 1 January 2021
Date Deposited: 13 Oct 2023 18:13
Last Modified: 13 Oct 2023 18:13

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