Do Place Cells Dream of Deceptive Moves in a Signaling Game?

Fenton, André A, Hurtado, José R, Broek, Jantine AC, Park, EunHye, Mishra, Bud (August 2023) Do Place Cells Dream of Deceptive Moves in a Signaling Game? Neuroscience, 529. pp. 129-147. ISSN 0306-4522

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Abstract

We consider the possibility of applying game theory to analysis and modeling of neurobiological systems. Specifically, the basic properties and features of information asymmetric signaling games are considered and discussed as having potential to explain diverse neurobiological phenomena; we focus on neuronal action potential discharge that can represent cognitive variables in memory and purposeful behavior. We begin by arguing that there is a pressing need for conceptual frameworks that can permit analysis and integration of information and explanations across many scales of biological function including gene regulation, molecular and biochemical signaling, cellular and metabolic function, neuronal population, and systems level organization to generate plausible hypotheses across these scales. Developing such integrative frameworks is crucial if we are to understand cognitive functions like learning, memory, and perception. The present work focuses on systems neuroscience organized around the connected brain regions of the entorhinal cortex and hippocampus. These areas are intensely studied in rodent subjects as model neuronal systems that undergo activity-dependent synaptic plasticity to form neuronal circuits and represent memories and spatial knowledge used for purposeful navigation. Examples of cognition-related spatial information in the observed neuronal discharge of hippocampal place cell populations and medial entorhinal head-direction cell populations are used to illustrate possible challenges to information maximization concepts. It may be natural to explain these observations using the ideas and features of information asymmetric signaling games.

Item Type:	Paper
Subjects:	organism description > animal behavior organism description > animal behavior > perception > cognition organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus organs, tissues, organelles, cell types and functions organism description > animal behavior > perception organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Mishra, Bud
Communities:	CSHL labs > Wigler lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	15 August 2023
Date Deposited:	12 Oct 2023 19:45
Last Modified:	08 Jan 2024 19:53
PMCID:	PMC10592151
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41214

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