Demisse, Rahel, Damle, Neha, Kim, Edward, Gong, Jun, Fakih, Marwan, Eng, Cathy, Oesterich, Leslie, McKenny, Madison, Ji, Jingran, Liu, James, Louie, Ryan, Tam, Kit, Gholami, Sepideh, Halabi, Wissam, Monjazeb, Arta, Dayyani, Farshid, Cho, May (July 2020) Neoadjuvant Immunotherapy-Based Systemic Treatment in MMR-Deficient or MSI-High Rectal Cancer: Case Series. Journal of the National Comprehensive Cancer Network : JNCCN, 18 (7). pp. 798-804. ISSN 1540-1405
Abstract
Treatment options for locally advanced rectal cancer have continued to consist largely of chemotherapy, chemoradiation, and/or surgical resection. For patients who are unable to undergo these therapeutic modalities or who do not to experience a response to them, treatment options are limited. We report 3 cases of mismatch repair-deficient (dMMR) locally advanced adenocarcinoma of the rectum that showed significant response with neoadjuvant immunotherapy-based systemic treatment. The first patient was not eligible for standard therapy because of a history of radiotherapy to the prostate with concurrent comorbidities and therefore received single-agent pembrolizumab. The second patient did not respond to total neoadjuvant chemoradiation and subsequently received combined nivolumab and ipilimumab. The third patient had a known family history of Lynch syndrome and presented with locally advanced rectal cancer and a baseline carcinoembryonic antigen level of 1,566 ng/mL. She was treated using neoadjuvant pembrolizumab and FOLFOX (folinic acid, fluorouracil, oxaliplatin). In this small series, we suggest that single-agent and combined-modality neoadjuvant immunotherapy/chemotherapy appear to be safe and effective treatment options for patients with (dMMR) locally advanced rectal cancer. Our findings encourage further studies to investigate the role of neoadjuvant immunotherapy as a viable treatment strategy in this population.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer diseases & disorders diseases & disorders > neoplasms diseases & disorders > cancer > cancer types > colon cancer diseases & disorders > cancer > cancer types > colon cancer diseases & disorders > cancer > drugs and therapies > Immunotherapy diseases & disorders > cancer > cancer types |
| CSHL Authors: | |
| Communities: | CSHL labs > Gholami Lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | July 2020 |
| Date Deposited: | 05 Oct 2023 17:35 |
| Last Modified: | 29 Jan 2024 21:05 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41134 |
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