Advances in Modeling the Immune Microenvironment of Colorectal Cancer

Yoon, Paul Sukwoo, Del Piccolo, Nuala, Shirure, Venktesh S, Peng, Yushuan, Kirane, Amanda, Canter, Robert J, Fields, Ryan C, George, Steven C, Gholami, Sepideh (2020) Advances in Modeling the Immune Microenvironment of Colorectal Cancer. Frontiers in Immunology, 11. p. 614300. ISSN 1664-3224

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Abstract

Colorectal cancer (CRC) is the third most common cancer and second leading cause of cancer-related death in the US. CRC frequently metastasizes to the liver and these patients have a particularly poor prognosis. The infiltration of immune cells into CRC tumors and liver metastases accurately predicts disease progression and patient survival. Despite the evident influence of immune cells in the CRC tumor microenvironment (TME), efforts to identify immunotherapies for CRC patients have been limited. Here, we argue that preclinical model systems that recapitulate key features of the tumor microenvironment-including tumor, stromal, and immune cells; the extracellular matrix; and the vasculature-are crucial for studies of immunity in the CRC TME and the utility of immunotherapies for CRC patients. We briefly review the discoveries, advantages, and disadvantages of current in vitro and in vivo model systems, including 2D cell culture models, 3D culture systems, murine models, and organ-on-a-chip technologies.

Item Type:	Paper
Subjects:	diseases & disorders > cancer diseases & disorders diseases & disorders > neoplasms diseases & disorders > cancer > cancer types > colon cancer diseases & disorders > cancer > cancer types > colon cancer diseases & disorders > cancer > drugs and therapies > Immunotherapy diseases & disorders > cancer > metastasis diseases & disorders > cancer > cancer types
CSHL Authors:	Gholami, Sepideh
Communities:	CSHL labs > Gholami Lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	2020
Date Deposited:	29 Sep 2023 19:57
Last Modified:	01 Feb 2024 19:45
PMCID:	PMC7902698
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41088

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