Targeting stressor-induced dysfunctions in protein-protein interaction networks via epichaperomes

Ginsberg, Stephen D, Sharma, Sahil, Norton, Larry, Chiosis, Gabriela (January 2023) Targeting stressor-induced dysfunctions in protein-protein interaction networks via epichaperomes. Trends in Pharmacological Sciences, 44 (1). pp. 20-33. ISSN 0165-6147

DOI: 10.1016/


Diseases are manifestations of complex changes in protein-protein interaction (PPI) networks whereby stressors, genetic, environmental, and combinations thereof, alter molecular interactions and perturb the individual from the level of cells and tissues to the entire organism. Targeting stressor-induced dysfunctions in PPI networks has therefore become a promising but technically challenging frontier in therapeutics discovery. This opinion provides a new framework based upon disrupting epichaperomes - pathological entities that enable dysfunctional rewiring of PPI networks - as a mechanism to revert context-specific PPI network dysfunction to a normative state. We speculate on the implications of recent research in this area for a precision medicine approach to detecting and treating complex diseases, including cancer and neurodegenerative disorders.

Item Type: Paper
Subjects: bioinformatics
diseases & disorders
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > Mapping and Rendering
diseases & disorders > neoplasms
CSHL Authors:
Communities: CSHL labs > Wigler lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: January 2023
Date Deposited: 28 Sep 2023 20:19
Last Modified: 08 Jan 2024 20:50
PMCID: PMC9789192
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