Ginsberg, Stephen D, Sharma, Sahil, Norton, Larry, Chiosis, Gabriela (January 2023) Targeting stressor-induced dysfunctions in protein-protein interaction networks via epichaperomes. Trends in Pharmacological Sciences, 44 (1). pp. 20-33. ISSN 0165-6147
Abstract
Diseases are manifestations of complex changes in protein-protein interaction (PPI) networks whereby stressors, genetic, environmental, and combinations thereof, alter molecular interactions and perturb the individual from the level of cells and tissues to the entire organism. Targeting stressor-induced dysfunctions in PPI networks has therefore become a promising but technically challenging frontier in therapeutics discovery. This opinion provides a new framework based upon disrupting epichaperomes - pathological entities that enable dysfunctional rewiring of PPI networks - as a mechanism to revert context-specific PPI network dysfunction to a normative state. We speculate on the implications of recent research in this area for a precision medicine approach to detecting and treating complex diseases, including cancer and neurodegenerative disorders.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics diseases & disorders bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > Mapping and Rendering diseases & disorders > neoplasms |
| CSHL Authors: | |
| Communities: | CSHL labs > Wigler lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | January 2023 |
| Date Deposited: | 28 Sep 2023 20:19 |
| Last Modified: | 08 Jan 2024 20:50 |
| PMCID: | PMC9789192 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41055 |
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