The Bruce effect: Representational stability and memory formation in the accessory olfactory bulb of the female mouse

Yoles-Frenkel, Michal, Shea, Stephen D, Davison, Ian G, Ben-Shaul, Yoram (August 2022) The Bruce effect: Representational stability and memory formation in the accessory olfactory bulb of the female mouse. Cell Reports, 40 (8). p. 111262. ISSN 2211-1247

PDF 2022-Shea-The Bruce effect.pdf Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (3MB)

Abstract

In the Bruce effect, a mated female mouse becomes resistant to the pregnancy-blocking effect of the stud. Various lines of evidence suggest that this form of behavioral imprinting results from reduced sensitivity of the female's accessory olfactory bulb (AOB) to the stud's chemosignals. However, the AOB's combinatorial code implies that diminishing responses to one individual will distort representations of other stimuli. Here, we record extracellular responses of AOB neurons in mated and unmated female mice while presenting urine stimuli from the stud and from other sources. We find that, while initial sensory responses in the AOB (within a timescale required to guide social interactions) remain stable, responses to extended stimulation (as required for eliciting the pregnancy block) display selective attenuation of stud-responsive neurons. Such temporal disassociation could allow attenuation of slow-acting endocrine processes in a stimulus-specific manner without compromising ongoing representations that guide behavior.

Item Type:	Paper
Subjects:	diseases & disorders organism description > animal organism description > animal behavior organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organism description > animal > gender > female organism description > animal > gender organism description > animal > mammal organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organism description > animal behavior > olfactory organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb organs, tissues, organelles, cell types and functions diseases & disorders > pregnancy organism description > animal > mammal > rodent organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Shea, Stephen D.
Communities:	CSHL labs > Shea lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	23 August 2022
Date Deposited:	06 Sep 2022 22:31
Last Modified:	17 Jan 2024 19:34
PMCID:	PMC9446479
URI:	https://repository.cshl.edu/id/eprint/40710

Actions (login required)

Administrator's edit/view item