The genomic basis of evolutionary differentiation among honey bees.

Fouks, Bertrand, Brand, Philipp, Nguyen, Hung N, Herman, Jacob, Camara, Francisco, Ence, Daniel, Hagen, Darren E, Hoff, Katharina J, Nachweide, Stefanie, Romoth, Lars, Walden, Kimberly KO, Guigo, Roderic, Stanke, Mario, Narzisi, Giuseppe, Yandell, Mark, Robertson, Hugh M, Koeniger, Nikolaus, Chantawannakul, Panuwan, Schatz, Michael C, Worley, Kim C, Robinson, Gene E, Elsik, Christine G, Rueppell, Olav (May 2021) The genomic basis of evolutionary differentiation among honey bees. Genome Research, 31 (7). pp. 1203-1215. ISSN 1088-9051

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Abstract

In contrast to the western honey bee, Apis mellifera, other honey bee species have been largely neglected despite their importance and diversity. The genetic basis of the evolutionary diversification of honey bees remains largely unknown. Here, we provide a genome-wide comparison of three honey bee species, each representing one of the three subgenera of honey bees, namely the dwarf (Apis florea), giant (A. dorsata), and cavity-nesting (A. mellifera) honey bees with bumblebees as an outgroup. Our analyses resolve the phylogeny of honey bees with the dwarf honey bees diverging first. We find that evolution of increased eusocial complexity in Apis proceeds via increases in the complexity of gene regulation, which is in agreement with previous studies. However, this process seems to be related to pathways other than transcriptional control. Positive selection patterns across Apis reveal a trade-off between maintaining genome stability and generating genetic diversity, with a rapidly evolving piRNA pathway leading to genomes depleted of transposable elements, and a rapidly evolving DNA repair pathway associated with high recombination rates in all Apis species. Diversification within Apis is accompanied by positive selection in several genes whose putative functions present candidate mechanisms for lineage-specific adaptations, such as migration, immunity, and nesting behavior.

Item Type:	Paper
Subjects:	bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics evolution bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes organism description > animal > insect
CSHL Authors:	Schatz, Michael C.
Communities:	CSHL labs > Schatz lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	4 May 2021
Date Deposited:	26 Jul 2021 13:27
Last Modified:	23 Jan 2024 21:08
PMCID:	PMC8256857
URI:	https://repository.cshl.edu/id/eprint/40298

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